WHO 2016 systemic mastocytosis (Valent 2016 Table 1)
WHO 2016 systemic mastocytosis (Valent 2016 Table 1). Met when major infiltrates (≥15 mast cells in aggregates in BM or extracutaneous organ) plus ≥1 minor, or ≥3 minors. Minors: >25% atypical/spindle mast cells, KIT codon 816, CD2 and/or CD25, tryptase >20 ng/mL (not valid with an unrelated myeloid neoplasm). Not a diagnosis. Not cutaneous mastocytosis only. Not ICC 2022. magent does not read a biopsy or assay tryptase.
Answeringour last check, 2026-10-10
1 of 1checks answered this week
272 msmedian answer time
$0.005listed price per call
$0.005price it asked us
Paid test badge: not yet. The checks above are free: we call the tool without paying and read the payment request it sends back. The Verified badge needs paid calls whose answers match the promised output, and nobody can buy a badge.
Endpoint
GET https://api.magentlab.com/api/calc/who_sm
| Category | Everything else |
|---|---|
| Provider host | api.magentlab.com |
| Networks | eip155:8453 |
| Payment schemes | batch-settlement, exact |
| Self-reported calls, 30 days | 4 from 3 payers (the provider's figure, not ours) |
Our checks, last 30 days
| Day | Result | HTTP | Asked | Time |
|---|---|---|---|---|
| 2026-10-10 | valid payment request | 402 | $0.005 | 272 ms |
Example input (from the provider)
{
"method": "GET",
"queryParams": {
"associated_myeloid_neoplasm": false,
"atypical_or_spindle": false,
"cd2_or_cd25": false,
"kit_codon_816": true,
"major_infiltrates": true,
"tryptase_gt_20": false
},
"type": "http"
}
Promised output schema (from the provider)
{
"$schema": "https://json-schema.org/draft/2020-12/schema",
"properties": {
"input": {
"additionalProperties": false,
"properties": {
"headers": {
"additionalProperties": {
"type": "string"
},
"type": "object"
},
"method": {
"enum": [
"GET",
"HEAD",
"DELETE"
],
"type": "string"
},
"queryParams": {
"properties": {
"associated_myeloid_neoplasm": {
"description": "Unrelated myeloid neoplasm present as assigned by the caller (Valent 2016 Table 1: item d is not valid). When true, tryptase_gt_20 does not count as a minor. true or false. magent does not diagnose a myeloid neoplasm.",
"type": "boolean"
},
"atypical_or_spindle": {
"description": ">25% atypical (type I/II) or spindle-shaped mast cells in infiltrates or smears, as assigned by the caller (Valent 2016 Table 1 minor a). true or false. magent does not read slides.",
"type": "boolean"
},
"cd2_or_cd25": {
"description": "Mast cells in bone marrow, blood, or another extracutaneous organ exhibit CD2 and/or CD25, as assigned by the caller (Valent 2016 Table 1 minor c). true or false. magent does not phenotype mast cells.",
"type": "boolean"
},
"kit_codon_816": {
"description": "KIT point mutation at codon 816 in bone marrow or another extracutaneous organ, as assigned by the caller (Valent 2016 Table 1 minor b). true or false. magent does not sequence KIT.",
"type": "boolean"
},
"major_infiltrates": {
"description": "Multifocal dense infiltrates of mast cells (\u226515 MCs in aggregates) in bone marrow or another extracutaneous organ, as assigned by the caller (Valent 2016 Table 1 major). true or false. magent does not read a biopsy.",
"type": "boolean"
},
"tryptase_gt_20": {
"description": "Baseline serum tryptase >20 ng/mL as assigned by the caller (Valent 2016 Table 1 minor d). Does not count when associated_myeloid_neoplasm is true. true or false. magent does not assay tryptase.",
"type": "boolean"
}
},
"required": [
"major_infiltrates",
"atypical_or_spindle",
"kit_codon_816",
"cd2_or_cd25",
"tryptase_gt_20",
"associated_myeloid_neoplasm"
],
"type": "object"
},
"type": {
"const": "http",
"type": "string"
}
},
"required": [
"type",
"method"
],
"type": "object"
},
"output": {
"properties": {
"example": {
"type": "object"
},
"type": {
"type": "string"
}
},
"required": [
"type"
],
"type": "object"
}
},
"required": [
"input"
],
"type": "object"
}