{"slug":"api-magentlab-com-api-calc-who-sm-2a3de3","title":"WHO 2016 systemic mastocytosis (Valent 2016 Table 1)","host":"api.magentlab.com","method":"GET","resource":"https://api.magentlab.com/api/calc/who_sm","category":"other","description":"WHO 2016 systemic mastocytosis (Valent 2016 Table 1). Met when major infiltrates (≥15 mast cells in aggregates in BM or extracutaneous organ) plus ≥1 minor, or ≥3 minors. Minors: >25% atypical/spindle mast cells, KIT codon 816, CD2 and/or CD25, tryptase >20 ng/mL (not valid with an unrelated myeloid","price_listed":0.005,"price_asked":0.005,"state":"answering","state_label":"Answering","checks_7d":1,"answered_7d":1,"latency_ms_median":272,"reported_calls_30d":4,"reported_payers_30d":3,"networks":["eip155:8453"],"badge":"unverified","paid_checks_7d":0,"paid_ok_7d":0,"example_input":{"method":"GET","queryParams":{"associated_myeloid_neoplasm":false,"atypical_or_spindle":false,"cd2_or_cd25":false,"kit_codon_816":true,"major_infiltrates":true,"tryptase_gt_20":false},"type":"http"},"output_schema":{"$schema":"https://json-schema.org/draft/2020-12/schema","properties":{"input":{"additionalProperties":false,"properties":{"headers":{"additionalProperties":{"type":"string"},"type":"object"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"queryParams":{"properties":{"associated_myeloid_neoplasm":{"description":"Unrelated myeloid neoplasm present as assigned by the caller (Valent 2016 Table 1: item d is not valid). When true, tryptase_gt_20 does not count as a minor. true or false. magent does not diagnose a myeloid neoplasm.","type":"boolean"},"atypical_or_spindle":{"description":">25% atypical (type I/II) or spindle-shaped mast cells in infiltrates or smears, as assigned by the caller (Valent 2016 Table 1 minor a). true or false. magent does not read slides.","type":"boolean"},"cd2_or_cd25":{"description":"Mast cells in bone marrow, blood, or another extracutaneous organ exhibit CD2 and/or CD25, as assigned by the caller (Valent 2016 Table 1 minor c). true or false. magent does not phenotype mast cells.","type":"boolean"},"kit_codon_816":{"description":"KIT point mutation at codon 816 in bone marrow or another extracutaneous organ, as assigned by the caller (Valent 2016 Table 1 minor b). true or false. magent does not sequence KIT.","type":"boolean"},"major_infiltrates":{"description":"Multifocal dense infiltrates of mast cells (≥15 MCs in aggregates) in bone marrow or another extracutaneous organ, as assigned by the caller (Valent 2016 Table 1 major). true or false. magent does not read a biopsy.","type":"boolean"},"tryptase_gt_20":{"description":"Baseline serum tryptase >20 ng/mL as assigned by the caller (Valent 2016 Table 1 minor d). Does not count when associated_myeloid_neoplasm is true. true or false. magent does not assay tryptase.","type":"boolean"}},"required":["major_infiltrates","atypical_or_spindle","kit_codon_816","cd2_or_cd25","tryptase_gt_20","associated_myeloid_neoplasm"],"type":"object"},"type":{"const":"http","type":"string"}},"required":["type","method"],"type":"object"},"output":{"properties":{"example":{"type":"object"},"type":{"type":"string"}},"required":["type"],"type":"object"}},"required":["input"],"type":"object"},"history":[{"day":"2026-10-10","reachable":true,"status":402,"valid_402":true,"asked_usdc":0.005,"price_match":true,"latency_ms":272,"error":null}],"description_full":"WHO 2016 systemic mastocytosis (Valent 2016 Table 1). Met when major infiltrates (≥15 mast cells in aggregates in BM or extracutaneous organ) plus ≥1 minor, or ≥3 minors. Minors: >25% atypical/spindle mast cells, KIT codon 816, CD2 and/or CD25, tryptase >20 ng/mL (not valid with an unrelated myeloid neoplasm). Not a diagnosis. Not cutaneous mastocytosis only. Not ICC 2022. magent does not read a biopsy or assay tryptase.","last_updated":"2026-10-08T06:14:33.503Z","schemes":["batch-settlement","exact"]}