ICC 2022 prefibrotic and overt PMF (Arber 2022)
ICC 2022 prefibrotic and overt PMF (Arber 2022). Diagnosed iff 3 majors and ≥1 minor. Majors: megakaryocyte morphology, not another myeloid neoplasm, JAK2/CALR/MPL or other clone or no reactive fibrosis. Minors: anemia not from comorbidity, WBC ≥11e9/L, splenomegaly, LDH above ULN; leukoerythroblastosis counts only in overt PMF. Not DIPSS, MIPSS70, WHO 5th, or post-PV/post-ET MF. magent does not read fibrosis grade or sequence drivers. Not a diagnosis or medical device.
Asked 1.4x its listed price for its own exampleour last check, 2026-09-28
1 of 1checks answered this week
344 msmedian answer time
$0.005listed price per call
$0.007price it asked us
Paid test badge: not yet. The checks above are free: we call the tool without paying and read the payment request it sends back. The Verified badge needs paid calls whose answers match the promised output, and nobody can buy a badge.
Endpoint
POST https://api.magentlab.com/api/calc/icc_pmf
| Category | Everything else |
|---|---|
| Provider host | api.magentlab.com |
| Networks | eip155:8453 |
| Payment schemes | exact |
| Self-reported calls, 30 days | 0 from 0 payers (the provider's figure, not ours) |
Our checks, last 30 days
| Day | Result | HTTP | Asked | Time |
|---|---|---|---|---|
| 2026-09-28 | valid payment request | 402 | $0.007 | 344 ms |
Example input (from the provider)
{
"body": {
"items": [
{
"anemia_not_comorbid": true,
"clonal_or_no_reactive": true,
"ldh_above_uln": false,
"leukocytosis_ge_11": false,
"leukoerythroblastosis": false,
"megakaryocyte_morphology": true,
"not_other_myeloid": true,
"phenotype": "pre",
"splenomegaly": false
},
{
"anemia_not_comorbid": true,
"clonal_or_no_reactive": true,
"ldh_above_uln": false,
"leukocytosis_ge_11": false,
"leukoerythroblastosis": false,
"megakaryocyte_morphology": true,
"not_other_myeloid": true,
"phenotype": "pre",
"splenomegaly": false
}
]
},
"method": "POST",
"type": "http"
}
Promised output schema (from the provider)
{
"$schema": "https://json-schema.org/draft/2020-12/schema",
"properties": {
"input": {
"additionalProperties": false,
"properties": {
"body": {
"additionalProperties": false,
"properties": {
"items": {
"items": {
"properties": {
"anemia_not_comorbid": {
"description": "Anemia not attributed to a comorbid condition, as assigned by the caller (Arber 2022 ICC PMF minor). true or false. magent does not assay hemoglobin.",
"type": "boolean"
},
"clonal_or_no_reactive": {
"description": "JAK2, CALR, or MPL mutation, or another clonal marker, or absence of reactive bone-marrow fibrosis, as assigned by the caller (Arber 2022 ICC PMF major). true or false. magent does not sequence.",
"type": "boolean"
},
"ldh_above_uln": {
"description": "LDH above the institutional upper limit of normal as assigned by the caller (Arber 2022 ICC PMF minor). true or false. magent does not assay LDH.",
"type": "boolean"
},
"leukocytosis_ge_11": {
"description": "Leukocytosis \u226511 \u00d7 10^9/L as assigned by the caller (Arber 2022 ICC PMF minor). true or false. magent does not assay WBC.",
"type": "boolean"
},
"leukoerythroblastosis": {
"description": "Leukoerythroblastosis as assigned by the caller (Arber 2022 ICC overt-PMF minor). Counts toward minor_count only when phenotype is overt; echoed but not counted when phenotype is pre. true or false. magent does not read a smear.",
"type": "boolean"
},
"megakaryocyte_morphology": {
"description": "Megakaryocytic proliferation and atypia for the chosen phenotype, as assigned by the caller (Arber 2022 ICC PMF major). For pre: without reticulin fibrosis grade >1, with increased age-adjusted cellularity, granulocytic proliferation, and often decreased erythropoiesis. For overt: accompanied by reticulin and/or collagen fibrosis grade 2 or 3. true or false. magent does not read a biopsy.",
"type": "boolean"
},
"not_other_myeloid": {
"description": "Does not meet ICC/WHO criteria for BCR::ABL1-positive CML, PV, ET, MDS, or another defined myeloid neoplasm, as assigned by the caller (Arber 2022 ICC PMF major). true or false. magent does not diagnose those neoplasms.",
"type": "boolean"
},
"phenotype": {
"description": "pre (prefibrotic/early PMF) or overt (overt fibrotic PMF) as assigned by the caller (Arber 2022 ICC). Required. magent does not assign phenotype from a biopsy.",
"enum": [
"pre",
"overt"
],
"type": "string"
},
"splenomegaly": {
"description": "Palpable splenomegaly as assigned by the caller (Arber 2022 ICC PMF minor). true or false. magent does not examine the spleen.",
"type": "boolean"
}
},
"required": [
"phenotype",
"megakaryocyte_morphology",
"not_other_myeloid",
"clonal_or_no_reactive",
"anemia_not_comorbid",
"leukocytosis_ge_11",
"splenomegaly",
"ldh_above_uln",
"leukoerythroblastosis"
],
"type": "object"
},
"maxItems": 25,
"minItems": 1,
"type": "array"
}
},
"required": [
"items"
],
"type": "object"
},
"headers": {
"additionalProperties": {
"type": "string"
},
"type": "object"
},
"method": {
"const": "POST",
"type": "string"
},
"type": {
"const": "http",
"type": "string"
}
},
"required": [
"type",
"method"
],
"type": "object"
},
"output": {
"properties": {
"example": {
"type": "object"
},
"type": {
"type": "string"
}
},
"required": [
"type"
],
"type": "object"
}
},
"required": [
"input"
],
"type": "object"
}