{"slug":"api-magentlab-com-api-calc-icc-pmf-4d2a2f","title":"ICC 2022 prefibrotic and overt PMF (Arber 2022)","host":"api.magentlab.com","method":"POST","resource":"https://api.magentlab.com/api/calc/icc_pmf","category":"other","description":"ICC 2022 prefibrotic and overt PMF (Arber 2022). Diagnosed iff 3 majors and ≥1 minor. Majors: megakaryocyte morphology, not another myeloid neoplasm, JAK2/CALR/MPL or other clone or no reactive fibrosis. Minors: anemia not from comorbidity, WBC ≥11e9/L, splenomegaly, LDH above ULN; leukoerythroblast","price_listed":0.005,"price_asked":0.007,"state":"overcharges","state_label":"Asked 1.4x its listed price for its own example","checks_7d":1,"answered_7d":1,"latency_ms_median":344,"reported_calls_30d":0,"reported_payers_30d":0,"networks":["eip155:8453"],"badge":"unverified","paid_checks_7d":0,"paid_ok_7d":0,"example_input":{"body":{"items":[{"anemia_not_comorbid":true,"clonal_or_no_reactive":true,"ldh_above_uln":false,"leukocytosis_ge_11":false,"leukoerythroblastosis":false,"megakaryocyte_morphology":true,"not_other_myeloid":true,"phenotype":"pre","splenomegaly":false},{"anemia_not_comorbid":true,"clonal_or_no_reactive":true,"ldh_above_uln":false,"leukocytosis_ge_11":false,"leukoerythroblastosis":false,"megakaryocyte_morphology":true,"not_other_myeloid":true,"phenotype":"pre","splenomegaly":false}]},"method":"POST","type":"http"},"output_schema":{"$schema":"https://json-schema.org/draft/2020-12/schema","properties":{"input":{"additionalProperties":false,"properties":{"body":{"additionalProperties":false,"properties":{"items":{"items":{"properties":{"anemia_not_comorbid":{"description":"Anemia not attributed to a comorbid condition, as assigned by the caller (Arber 2022 ICC PMF minor). true or false. magent does not assay hemoglobin.","type":"boolean"},"clonal_or_no_reactive":{"description":"JAK2, CALR, or MPL mutation, or another clonal marker, or absence of reactive bone-marrow fibrosis, as assigned by the caller (Arber 2022 ICC PMF major). true or false. magent does not sequence.","type":"boolean"},"ldh_above_uln":{"description":"LDH above the institutional upper limit of normal as assigned by the caller (Arber 2022 ICC PMF minor). true or false. magent does not assay LDH.","type":"boolean"},"leukocytosis_ge_11":{"description":"Leukocytosis ≥11 × 10^9/L as assigned by the caller (Arber 2022 ICC PMF minor). true or false. magent does not assay WBC.","type":"boolean"},"leukoerythroblastosis":{"description":"Leukoerythroblastosis as assigned by the caller (Arber 2022 ICC overt-PMF minor). Counts toward minor_count only when phenotype is overt; echoed but not counted when phenotype is pre. true or false. magent does not read a smear.","type":"boolean"},"megakaryocyte_morphology":{"description":"Megakaryocytic proliferation and atypia for the chosen phenotype, as assigned by the caller (Arber 2022 ICC PMF major). For pre: without reticulin fibrosis grade >1, with increased age-adjusted cellularity, granulocytic proliferation, and often decreased erythropoiesis. For overt: accompanied by reticulin and/or collagen fibrosis grade 2 or 3. true or false. magent does not read a biopsy.","type":"boolean"},"not_other_myeloid":{"description":"Does not meet ICC/WHO criteria for BCR::ABL1-positive CML, PV, ET, MDS, or another defined myeloid neoplasm, as assigned by the caller (Arber 2022 ICC PMF major). true or false. magent does not diagnose those neoplasms.","type":"boolean"},"phenotype":{"description":"pre (prefibrotic/early PMF) or overt (overt fibrotic PMF) as assigned by the caller (Arber 2022 ICC). 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Diagnosed iff 3 majors and ≥1 minor. Majors: megakaryocyte morphology, not another myeloid neoplasm, JAK2/CALR/MPL or other clone or no reactive fibrosis. Minors: anemia not from comorbidity, WBC ≥11e9/L, splenomegaly, LDH above ULN; leukoerythroblastosis counts only in overt PMF. Not DIPSS, MIPSS70, WHO 5th, or post-PV/post-ET MF. magent does not read fibrosis grade or sequence drivers. Not a diagnosis or medical device.","last_updated":"2026-09-28T15:09:53.437Z","schemes":["exact"]}