Cuker 2010 HEP score

Cuker 2010 HEP score: eight features with signed weights (range -16 to 19). Magnitude of platelet fall, typical- or rapid-onset timing, nadir, thrombosis (at most one), SQ heparin skin necrosis, IV-bolus systemic reaction, bleeding, and other causes (select all; no other cause +3). Cutoff 2 was 100% sensitive / 60% specific vs the expert panel. Not a HIT diagnosis or 4Ts score. magent does not assay SRA or ELISA.

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Endpoint

POST https://api.magentlab.com/api/calc/hep

Our checks, last 30 days

Example input (from the provider)

{
  "body": {
    "items": [
      {
        "bleeding": false,
        "chronic_thrombocytopenia": false,
        "cpb_96h": false,
        "intra_arterial_device": false,
        "magnitude": "gt_50",
        "nadir": "gt_20",
        "new_drug_thrombocytopenia": false,
        "no_other_cause": true,
        "overt_dic": false,
        "severe_infection": false,
        "skin_necrosis": false,
        "systemic_reaction": false,
        "thrombosis": "typical_new_ge_4d",
        "timing": "typical_5_10"
      },
      {
        "bleeding": false,
        "chronic_thrombocytopenia": false,
        "cpb_96h": false,
        "intra_arterial_device": false,
        "magnitude": "gt_50",
        "nadir": "gt_20",
        "new_drug_thrombocytopenia": false,
        "no_other_cause": true,
        "overt_dic": false,
        "severe_infection": false,
        "skin_necrosis": false,
        "systemic_reaction": false,
        "thrombosis": "typical_new_ge_4d",
        "timing": "typical_5_10"
      }
    ]
  },
  "method": "POST",
  "type": "http"
}

Promised output schema (from the provider)

{
  "$schema": "https://json-schema.org/draft/2020-12/schema",
  "properties": {
    "input": {
      "additionalProperties": false,
      "properties": {
        "body": {
          "additionalProperties": false,
          "properties": {
            "items": {
              "items": {
                "properties": {
                  "bleeding": {
                    "description": "Presence of bleeding, petechiae, or extensive bruising (Cuker 2010). true scores -1; false scores 0.",
                    "type": "boolean"
                  },
                  "chronic_thrombocytopenia": {
                    "description": "Presence of a chronic thrombocytopenic disorder (Cuker 2010 other causes; select all that apply). true scores -1. Mutually exclusive with no_other_cause true.",
                    "type": "boolean"
                  },
                  "cpb_96h": {
                    "description": "Cardiopulmonary bypass within the previous 96 hours (Cuker 2010). true scores -1. Mutually exclusive with no_other_cause true.",
                    "type": "boolean"
                  },
                  "intra_arterial_device": {
                    "description": "Indwelling intra-arterial device (Cuker 2010 examples: IABP, VAD, ECMO). true scores -2. Mutually exclusive with no_other_cause true.",
                    "type": "boolean"
                  },
                  "magnitude": {
                    "description": "Caller-assigned Cuker 2010 magnitude of platelet fall (peak to nadir since heparin exposure). lt_30 (<30%) scores -1; 30_to_50 (30-50%) scores 1; gt_50 (>50%) scores 3. magent does not grade platelet counts.",
                    "type": "string"
                  },
                  "nadir": {
                    "description": "Caller-assigned Cuker 2010 nadir platelet count. le_20 (\u226420 \u00d710^9/L) scores -2; gt_20 (>20 \u00d710^9/L) scores 2. magent does not take a raw platelet count.",
                    "type": "string"
                  },
                  "new_drug_thrombocytopenia": {
                    "description": "Newly initiated non-heparin medication known to cause thrombocytopenia (Cuker 2010). true scores -2. Mutually exclusive with no_other_cause true.",
                    "type": "boolean"
                  },
                  "no_other_cause": {
                    "description": "No other apparent cause of thrombocytopenia (Cuker 2010). true scores 3. Must be false if any other-cause flag is true.",
                    "type": "boolean"
                  },
                  "overt_dic": {
                    "description": "Overt DIC as assigned by the caller (Cuker 2010: fibrinogen <100 mg/dL and D-dimer >5.0 \u03bcg/mL). true scores -2. magent does not assay fibrinogen or D-dimer. Mutually exclusive with no_other_cause true.",
                    "type": "boolean"
                  },
                  "severe_infection": {
                    "description": "Severe infection as an other cause of thrombocytopenia (Cuker 2010). true scores -2. Mutually exclusive with no_other_cause true.",
                    "type": "boolean"
                  },
                  "skin_necrosis": {
                    "description": "Skin necrosis at subcutaneous heparin injection sites (Cuker 2010). true scores 3; false scores 0. magent does not examine the skin.",
                    "type": "boolean"
                  },
                  "systemic_reaction": {
                    "description": "Acute systemic reaction after intravenous heparin bolus (Cuker 2010). true scores 2; false scores 0.",
                    "type": "boolean"
                  },
                  "thrombosis": {
                    "description": "Caller-assigned Cuker 2010 thrombosis (select at most one). none scores 0. Typical-onset: typical_new_ge_4d (new VTE or ATE \u22654 days after heparin) 3; typical_progression (progression of preexisting VTE or ATE while receiving heparin) 2. Rapid-onset: rapid_new (new VTE or ATE after heparin) 3; rapid_progression 2.",
                    "type": "string"
                  },
                  "timing": {
                    "description": "Caller-assigned Cuker 2010 timing. Typical-onset: typical_lt_4 (fall begins <4 days) -2; typical_day_4 (day 4) 2; typical_5_10 (days 5-10) 3; typical_11_14 (days 11-14) 2; typical_gt_14 (>14 days) -1. Rapid-onset after re-exposure within 100 days: rapid_lt_48h (<48 h) 2; rapid_gt_48h (>48 h) -1. magent does not infer day of onset.",
                    "type": "string"
                  }
                },
                "required": [
                  "magnitude",
                  "timing",
                  "nadir",
                  "thrombosis",
                  "skin_necrosis",
                  "systemic_reaction",
                  "bleeding",
                  "chronic_thrombocytopenia",
                  "new_drug_thrombocytopenia",
                  "severe_infection",
                  "overt_dic",
                  "intra_arterial_device",
                  "cpb_96h",
                  "no_other_cause"
                ],
                "type": "object"
              },
              "maxItems": 25,
              "minItems": 1,
              "type": "array"
            }
          },
          "required": [
            "items"
          ],
          "type": "object"
        },
        "headers": {
          "additionalProperties": {
            "type": "string"
          },
          "type": "object"
        },
        "method": {
          "const": "POST",
          "type": "string"
        },
        "type": {
          "const": "http",
          "type": "string"
        }
      },
      "required": [
        "type",
        "method"
      ],
      "type": "object"
    },
    "output": {
      "properties": {
        "example": {
          "type": "object"
        },
        "type": {
          "type": "string"
        }
      },
      "required": [
        "type"

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