WHO 2016 systemic mastocytosis (Valent 2016 Table 1)

WHO 2016 systemic mastocytosis (Valent 2016 Table 1). Met when major infiltrates (≥15 mast cells in aggregates in BM or extracutaneous organ) plus ≥1 minor, or ≥3 minors. Minors: >25% atypical/spindle mast cells, KIT codon 816, CD2 and/or CD25, tryptase >20 ng/mL (not valid with an unrelated myeloid neoplasm). Not a diagnosis. Not cutaneous mastocytosis only. Not ICC 2022. magent does not read a biopsy or assay tryptase.

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Endpoint

POST https://api.magentlab.com/api/calc/who_sm

Our checks, last 30 days

Example input (from the provider)

{
  "body": {
    "items": [
      {
        "associated_myeloid_neoplasm": false,
        "atypical_or_spindle": false,
        "cd2_or_cd25": false,
        "kit_codon_816": true,
        "major_infiltrates": true,
        "tryptase_gt_20": false
      },
      {
        "associated_myeloid_neoplasm": false,
        "atypical_or_spindle": false,
        "cd2_or_cd25": false,
        "kit_codon_816": true,
        "major_infiltrates": true,
        "tryptase_gt_20": false
      }
    ]
  },
  "method": "POST",
  "type": "http"
}

Promised output schema (from the provider)

{
  "$schema": "https://json-schema.org/draft/2020-12/schema",
  "properties": {
    "input": {
      "additionalProperties": false,
      "properties": {
        "body": {
          "additionalProperties": false,
          "properties": {
            "items": {
              "items": {
                "properties": {
                  "associated_myeloid_neoplasm": {
                    "description": "Unrelated myeloid neoplasm present as assigned by the caller (Valent 2016 Table 1: item d is not valid). When true, tryptase_gt_20 does not count as a minor. true or false. magent does not diagnose a myeloid neoplasm.",
                    "type": "boolean"
                  },
                  "atypical_or_spindle": {
                    "description": ">25% atypical (type I/II) or spindle-shaped mast cells in infiltrates or smears, as assigned by the caller (Valent 2016 Table 1 minor a). true or false. magent does not read slides.",
                    "type": "boolean"
                  },
                  "cd2_or_cd25": {
                    "description": "Mast cells in bone marrow, blood, or another extracutaneous organ exhibit CD2 and/or CD25, as assigned by the caller (Valent 2016 Table 1 minor c). true or false. magent does not phenotype mast cells.",
                    "type": "boolean"
                  },
                  "kit_codon_816": {
                    "description": "KIT point mutation at codon 816 in bone marrow or another extracutaneous organ, as assigned by the caller (Valent 2016 Table 1 minor b). true or false. magent does not sequence KIT.",
                    "type": "boolean"
                  },
                  "major_infiltrates": {
                    "description": "Multifocal dense infiltrates of mast cells (\u226515 MCs in aggregates) in bone marrow or another extracutaneous organ, as assigned by the caller (Valent 2016 Table 1 major). true or false. magent does not read a biopsy.",
                    "type": "boolean"
                  },
                  "tryptase_gt_20": {
                    "description": "Baseline serum tryptase >20 ng/mL as assigned by the caller (Valent 2016 Table 1 minor d). Does not count when associated_myeloid_neoplasm is true. true or false. magent does not assay tryptase.",
                    "type": "boolean"
                  }
                },
                "required": [
                  "major_infiltrates",
                  "atypical_or_spindle",
                  "kit_codon_816",
                  "cd2_or_cd25",
                  "tryptase_gt_20",
                  "associated_myeloid_neoplasm"
                ],
                "type": "object"
              },
              "maxItems": 25,
              "minItems": 1,
              "type": "array"
            }
          },
          "required": [
            "items"
          ],
          "type": "object"
        },
        "headers": {
          "additionalProperties": {
            "type": "string"
          },
          "type": "object"
        },
        "method": {
          "const": "POST",
          "type": "string"
        },
        "type": {
          "const": "http",
          "type": "string"
        }
      },
      "required": [
        "type",
        "method"
      ],
      "type": "object"
    },
    "output": {
      "properties": {
        "example": {
          "type": "object"
        },
        "type": {
          "type": "string"
        }
      },
      "required": [
        "type"
      ],
      "type": "object"
    }
  },
  "required": [
    "input"
  ],
  "type": "object"
}

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