Guglielmelli 2018 MIPSS70 for transplant-age PMF

Guglielmelli 2018 MIPSS70 for transplant-age PMF: Hb <10 g/dL (1), leukocytes >25×10^9/L (2), platelets <100×10^9/L (2), blasts ≥2% (1), fibrosis ≥2 (1), symptoms (1), no type 1/like CALR (1), HMR category (1), ≥2 HMR (2); max 12. Low 0–1, intermediate 2–4, high ≥5. Italian-cohort median (5-year) OS 27.7 y (95%), 7.1 y (70%), 2.3 y (29%). Not MIPSS70-plus or version 2.0. magent does not sequence or grade marrow.

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Endpoint

POST https://api.magentlab.com/api/calc/mipss70

Our checks, last 30 days

Example input (from the provider)

{
  "body": {
    "items": [
      {
        "blasts_percent": 0,
        "calr_type1_like": true,
        "constitutional_symptoms": false,
        "fibrosis_grade": 1,
        "hemoglobin_g_dl": 12,
        "hemoglobin_g_l": 120,
        "hmr_mutation_count": 0,
        "leukocytes_10e9_l": 10,
        "platelets_10e9_l": 200
      },
      {
        "blasts_percent": 0,
        "calr_type1_like": true,
        "constitutional_symptoms": false,
        "fibrosis_grade": 1,
        "hemoglobin_g_dl": 12,
        "hemoglobin_g_l": 120,
        "hmr_mutation_count": 0,
        "leukocytes_10e9_l": 10,
        "platelets_10e9_l": 200
      }
    ]
  },
  "method": "POST",
  "type": "http"
}

Promised output schema (from the provider)

{
  "$schema": "https://json-schema.org/draft/2020-12/schema",
  "properties": {
    "input": {
      "additionalProperties": false,
      "properties": {
        "body": {
          "additionalProperties": false,
          "properties": {
            "items": {
              "items": {
                "properties": {
                  "blasts_percent": {
                    "description": "Circulating blasts as a percent (0-30). \u22652 scores 1 (Guglielmelli 2018). 2.0 scores; 1.9 is the <2 arm and scores 0. magent does not read a smear.",
                    "type": "number"
                  },
                  "calr_type1_like": {
                    "description": "Presence of a type 1/like CALR mutation as assigned by the caller (Guglielmelli 2018). false (absence) scores 1. true scores 0. magent does not sequence.",
                    "type": "boolean"
                  },
                  "constitutional_symptoms": {
                    "description": "Constitutional symptoms as assigned by the caller (Guglielmelli 2018). true scores 1. magent does not take a history.",
                    "type": "boolean"
                  },
                  "fibrosis_grade": {
                    "description": "WHO bone-marrow fibrosis grade as an integer 0-3, assigned by the caller (Guglielmelli 2018). \u22652 scores 1. Grade 2 scores; grade 1 scores 0. magent does not grade marrow.",
                    "type": "integer"
                  },
                  "hemoglobin_g_dl": {
                    "description": "Hemoglobin in g/dL (3-22). Provide this or hemoglobin_g_l, not both. <10 g/dL (<100 g/L) scores 1 (Guglielmelli 2018). 10.0 is the \u226510 arm and scores 0. magent does not assay hemoglobin.",
                    "type": "number"
                  },
                  "hemoglobin_g_l": {
                    "description": "Hemoglobin in g/L (30-220). Converted as hemoglobin_g_dl = hemoglobin_g_l / 10. Provide this or hemoglobin_g_dl, not both. <100 g/L scores 1. 100 is the \u2265100 arm and scores 0.",
                    "type": "number"
                  },
                  "hmr_mutation_count": {
                    "description": "Count of high-molecular-risk mutations among ASXL1, EZH2, SRSF2, IDH1, and IDH2 as assigned by the caller (integer 0-5). \u22651 scores 1 (HMR category). \u22652 scores an additional 2 (two or more HMR mutations), so a count of 2 or more contributes 3. Count 0 scores 0. magent does not sequence.",
                    "type": "integer"
                  },
                  "leukocytes_10e9_l": {
                    "description": "Leukocyte count in 10^9/L (0.5-200). >25 scores 2 (Guglielmelli 2018). 25.0 is the \u226425 arm and scores 0. magent does not assay leukocytes.",
                    "type": "number"
                  },
                  "platelets_10e9_l": {
                    "description": "Platelet count in 10^9/L (1-2000). <100 scores 2 (Guglielmelli 2018). 100.0 is the \u2265100 arm and scores 0. magent does not assay platelets.",
                    "type": "number"
                  }
                },
                "required": [
                  "leukocytes_10e9_l",
                  "platelets_10e9_l",
                  "blasts_percent",
                  "fibrosis_grade",
                  "constitutional_symptoms",
                  "calr_type1_like",
                  "hmr_mutation_count"
                ],
                "type": "object"
              },
              "maxItems": 25,
              "minItems": 1,
              "type": "array"
            }
          },
          "required": [
            "items"
          ],
          "type": "object"
        },
        "headers": {
          "additionalProperties": {
            "type": "string"
          },
          "type": "object"
        },
        "method": {
          "const": "POST",
          "type": "string"
        },
        "type": {
          "const": "http",
          "type": "string"
        }
      },
      "required": [
        "type",
        "method"
      ],
      "type": "object"
    },
    "output": {
      "properties": {
        "example": {
          "type": "object"
        },
        "type": {
          "type": "string"
        }
      },
      "required": [
        "type"
      ],
      "type": "object"
    }
  },
  "required": [
    "input"
  ],
  "type": "object"
}

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