2024 McDonald typical CIS (Montalban 2025)
2024 McDonald typical CIS (Montalban 2025). mcdonald_ms iff typical_cis and no_better_explanation and: ≥2 attacks with ≥2 lesions; or ≥2 attacks with one lesion plus DIS; or CIS with ≥2 lesions plus MRI DIT, OCB, or kappa FLC; or CIS with one lesion plus DIS and MRI DIT, OCB, or kappa FLC. DIS = ≥2 of 5 topographies (optic nerve added). Kappa FLC interchangeable with OCB. Not 2017 McDonald. Not PPMS. Not RIS. magent does not read MRI or assay CSF. Not a diagnosis. Not a medical device.
Asked 1.4x its listed price for its own exampleour last check, 2026-09-28
1 of 1checks answered this week
354 msmedian answer time
$0.005listed price per call
$0.007price it asked us
Paid test badge: not yet. The checks above are free: we call the tool without paying and read the payment request it sends back. The Verified badge needs paid calls whose answers match the promised output, and nobody can buy a badge.
Endpoint
POST https://api.magentlab.com/api/calc/mcdonald_2024
| Category | Everything else |
|---|---|
| Provider host | api.magentlab.com |
| Networks | eip155:8453 |
| Payment schemes | exact |
| Self-reported calls, 30 days | 0 from 0 payers (the provider's figure, not ours) |
Our checks, last 30 days
| Day | Result | HTTP | Asked | Time |
|---|---|---|---|---|
| 2026-09-28 | valid payment request | 402 | $0.007 | 354 ms |
Example input (from the provider)
{
"body": {
"items": [
{
"cortical_or_juxtacortical": false,
"csf_kflc": false,
"csf_specific_ocb": false,
"dit_mri": false,
"infratentorial": false,
"no_better_explanation": true,
"optic_nerve": false,
"periventricular": false,
"spinal_cord": false,
"two_or_more_attacks": true,
"two_or_more_lesions": true,
"typical_cis": true
},
{
"cortical_or_juxtacortical": false,
"csf_kflc": false,
"csf_specific_ocb": false,
"dit_mri": false,
"infratentorial": false,
"no_better_explanation": true,
"optic_nerve": false,
"periventricular": false,
"spinal_cord": false,
"two_or_more_attacks": true,
"two_or_more_lesions": true,
"typical_cis": true
}
]
},
"method": "POST",
"type": "http"
}
Promised output schema (from the provider)
{
"$schema": "https://json-schema.org/draft/2020-12/schema",
"properties": {
"input": {
"additionalProperties": false,
"properties": {
"body": {
"additionalProperties": false,
"properties": {
"items": {
"items": {
"properties": {
"cortical_or_juxtacortical": {
"description": "Caller-assigned typical cortical or juxtacortical MS lesion topography (one of five 2024 DIS locations). true or false. magent does not read MRI.",
"type": "boolean"
},
"csf_kflc": {
"description": "CSF kappa free-light chains positive as assigned by the caller (2024: interchangeable with oligoclonal bands as the CSF DIT marker). Caller-assigned flag only; this tool does not apply a numeric kFLC index cutoff. true or false. magent does not assay CSF.",
"type": "boolean"
},
"csf_specific_ocb": {
"description": "CSF-specific oligoclonal bands as assigned by the caller (2024 DIT substitute; interchangeable with kappa free-light chains). true or false. magent does not assay CSF.",
"type": "boolean"
},
"dit_mri": {
"description": "MRI dissemination in time as assigned by the caller (simultaneous Gd-enhancing and non-enhancing lesions, or a new T2 or Gd-enhancing lesion on follow-up vs baseline). true or false. magent does not read MRI.",
"type": "boolean"
},
"infratentorial": {
"description": "Caller-assigned typical infratentorial MS lesion topography (one of five 2024 DIS locations). true or false. magent does not read MRI.",
"type": "boolean"
},
"no_better_explanation": {
"description": "No better explanation for the presentation as assigned by the caller (Montalban 2025). If false, mcdonald_ms is false. Remain vigilant for NMOSD. true or false. magent does not assign a better explanation.",
"type": "boolean"
},
"optic_nerve": {
"description": "Caller-assigned typical optic-nerve topography (fifth 2024 DIS location; Montalban 2025). true or false. magent does not read MRI, OCT, or VEP.",
"type": "boolean"
},
"periventricular": {
"description": "Caller-assigned typical periventricular MS lesion topography (one of five 2024 DIS locations). true or false. magent does not read MRI.",
"type": "boolean"
},
"spinal_cord": {
"description": "Caller-assigned typical spinal-cord MS lesion topography (one of five 2024 DIS locations). true or false. magent does not read MRI.",
"type": "boolean"
},
"two_or_more_attacks": {
"description": "\u22652 clinical attacks as assigned by the caller. true means two or more attacks; false means this is the first/CIS attack. true or false. magent does not date attacks.",
"type": "boolean"
},
"two_or_more_lesions": {
"description": "Objective clinical evidence of \u22652 lesions as assigned by the caller. true means \u22652 lesions; false means 1 lesion. true or false. magent does not examine the patient.",
"type": "boolean"
},
"typical_cis": {
"description": "Typical clinically isolated syndrome as assigned by the caller (Montalban 2025 typical CIS / relapsing pathway). If false, mcdonald_ms is false; this tool does not diagnose MS from atypical presentations, PPMS, or RIS. true or false. magent does not examine the patient.",
"type": "boolean"
}
},
"required": [
"typical_cis",
"no_better_explanation",
"two_or_more_attacks",
"two_or_more_lesions",
"periventricular",
"cortical_or_juxtacortical",
"infratentorial",
"spinal_cord",
"optic_nerve",
"dit_mri",
"csf_specific_ocb",
"csf_kflc"
],
"type": "object"
},
"maxItems": 25,
"minItems": 1,
"type": "array"
}
},
"required": [
"items"
],
"type": "object"
},
"headers": {
"additionalProperties": {
"type": "string"
},
"type": "object"
},
"method": {
"const": "POST",
"type": "string"
},
"type": {
"const": "http",
"type": "string"
}
},
"required": [
"type",
"method"
],
"type": "object"
},
"output": {
"properties": {
"example": {
"type": "object"
},
"type": {
"type": "string"
}
},
"required": [
"type"
],
"type": "object"
}
},
"required": [
"input"
],
"type": "object"
}