2017 McDonald typical CIS (Thompson 2018)

2017 McDonald typical CIS (Thompson 2018). mcdonald_ms iff typical_cis and no_better_explanation and: ≥2 attacks with ≥2 lesions; or ≥2 attacks with one lesion plus DIS; or CIS with ≥2 lesions plus MRI DIT or CSF-specific OCB; or CIS with one lesion plus DIS and MRI DIT or CSF-specific OCB. 2017: OCB may substitute for DIT when DIS is met. Symptomatic and cortical lesions count. Not PPMS. Not 2010 McDonald. magent does not read MRI or CSF. Not a diagnosis. Not a medical device.

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Endpoint

POST https://api.magentlab.com/api/calc/mcdonald_2017

Our checks, last 30 days

Example input (from the provider)

{
  "body": {
    "items": [
      {
        "csf_specific_ocb": false,
        "dis": false,
        "dit_mri": false,
        "no_better_explanation": true,
        "two_or_more_attacks": true,
        "two_or_more_lesions": true,
        "typical_cis": true
      },
      {
        "csf_specific_ocb": false,
        "dis": false,
        "dit_mri": false,
        "no_better_explanation": true,
        "two_or_more_attacks": true,
        "two_or_more_lesions": true,
        "typical_cis": true
      }
    ]
  },
  "method": "POST",
  "type": "http"
}

Promised output schema (from the provider)

{
  "$schema": "https://json-schema.org/draft/2020-12/schema",
  "properties": {
    "input": {
      "additionalProperties": false,
      "properties": {
        "body": {
          "additionalProperties": false,
          "properties": {
            "items": {
              "items": {
                "properties": {
                  "csf_specific_ocb": {
                    "description": "CSF-specific oligoclonal bands as assigned by the caller (2017 DIT substitute when DIS is fulfilled). true or false. magent does not assay CSF.",
                    "type": "boolean"
                  },
                  "dis": {
                    "description": "Dissemination in space as assigned by the caller (2017: \u22651 T2-hyperintense lesion characteristic of MS in \u22652 of 4 areas: periventricular, cortical or juxtacortical, infratentorial, spinal cord; symptomatic lesions count; cortical lesions count). true or false. magent does not read MRI.",
                    "type": "boolean"
                  },
                  "dit_mri": {
                    "description": "MRI dissemination in time as assigned by the caller (simultaneous Gd-enhancing and non-enhancing lesions, or a new T2 or Gd-enhancing lesion on follow-up vs baseline). true or false. magent does not read MRI.",
                    "type": "boolean"
                  },
                  "no_better_explanation": {
                    "description": "No better explanation for the presentation as assigned by the caller (Thompson 2018). If false, mcdonald_ms is false. Remain vigilant for NMOSD. true or false. magent does not assign a better explanation.",
                    "type": "boolean"
                  },
                  "two_or_more_attacks": {
                    "description": "\u22652 clinical attacks as assigned by the caller. true means two or more attacks; false means this is the first/CIS attack. true or false. magent does not date attacks.",
                    "type": "boolean"
                  },
                  "two_or_more_lesions": {
                    "description": "Objective clinical evidence of \u22652 lesions as assigned by the caller. true means \u22652 lesions; false means 1 lesion. true or false. magent does not examine the patient.",
                    "type": "boolean"
                  },
                  "typical_cis": {
                    "description": "Typical clinically isolated syndrome as assigned by the caller (Thompson 2018 panel 1). If false, mcdonald_ms is false; this tool does not diagnose MS from atypical presentations. true or false. magent does not examine the patient.",
                    "type": "boolean"
                  }
                },
                "required": [
                  "typical_cis",
                  "no_better_explanation",
                  "two_or_more_attacks",
                  "two_or_more_lesions",
                  "dis",
                  "dit_mri",
                  "csf_specific_ocb"
                ],
                "type": "object"
              },
              "maxItems": 25,
              "minItems": 1,
              "type": "array"
            }
          },
          "required": [
            "items"
          ],
          "type": "object"
        },
        "headers": {
          "additionalProperties": {
            "type": "string"
          },
          "type": "object"
        },
        "method": {
          "const": "POST",
          "type": "string"
        },
        "type": {
          "const": "http",
          "type": "string"
        }
      },
      "required": [
        "type",
        "method"
      ],
      "type": "object"
    },
    "output": {
      "properties": {
        "example": {
          "type": "object"
        },
        "type": {
          "type": "string"
        }
      },
      "required": [
        "type"
      ],
      "type": "object"
    }
  },
  "required": [
    "input"
  ],
  "type": "object"
}

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