ASCO 2018 (Brahmer) immune-related hepatitis grade from caller AST, ALT, and tot

ASCO 2018 (Brahmer) immune-related hepatitis grade from caller AST, ALT, and total bilirubin as folds of laboratory ULN (mg/dL only). Lab grade is the max of transaminase and bilirubin Table 2.2 bands; decompensated liver upgrades to grade 4; symptomatic compensated liver dysfunction upgrades to grade 3. ICI action: continue (0-1), hold (2), or permanently discontinue (3-4). Not a medical device, not a diagnosis, not DILI/RUCAM, not R factor, not a steroid dose; magent does not assay enzymes.

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Endpoint

POST https://api.magentlab.com/api/calc/irae_hepatitis

Our checks, last 30 days

Example input (from the provider)

{
  "body": {
    "items": [
      {
        "alt_u_l": 50,
        "alt_uln_u_l": 40,
        "ast_u_l": 80,
        "ast_uln_u_l": 40,
        "bilirubin_mg_dl": 1,
        "bilirubin_uln_mg_dl": 1,
        "decompensated_liver": false,
        "symptomatic_liver_dysfunction": false
      },
      {
        "alt_u_l": 50,
        "alt_uln_u_l": 40,
        "ast_u_l": 80,
        "ast_uln_u_l": 40,
        "bilirubin_mg_dl": 1,
        "bilirubin_uln_mg_dl": 1,
        "decompensated_liver": false,
        "symptomatic_liver_dysfunction": false
      }
    ]
  },
  "method": "POST",
  "type": "http"
}

Promised output schema (from the provider)

{
  "$schema": "https://json-schema.org/draft/2020-12/schema",
  "properties": {
    "input": {
      "additionalProperties": false,
      "properties": {
        "body": {
          "additionalProperties": false,
          "properties": {
            "items": {
              "items": {
                "properties": {
                  "alt_u_l": {
                    "description": "Alanine aminotransferase in U/L (1-10000). Used with alt_uln_u_l for the ALT fold. magent does not assay enzymes.",
                    "type": "number"
                  },
                  "alt_uln_u_l": {
                    "description": "Laboratory ALT upper limit of normal in U/L (5-200). Required; magent does not assume 40.",
                    "type": "number"
                  },
                  "ast_u_l": {
                    "description": "Aspartate aminotransferase in U/L (1-10000). Used with ast_uln_u_l for the AST fold. magent does not assay enzymes.",
                    "type": "number"
                  },
                  "ast_uln_u_l": {
                    "description": "Laboratory AST upper limit of normal in U/L (5-200). Required; magent does not assume 40.",
                    "type": "number"
                  },
                  "bilirubin_mg_dl": {
                    "description": "Total bilirubin in mg/dL (0.1-40). \u00b5mol/L is not accepted. magent does not assay bilirubin.",
                    "type": "number"
                  },
                  "bilirubin_uln_mg_dl": {
                    "description": "Laboratory total-bilirubin upper limit of normal in mg/dL (0.1-5). Required; magent does not assume 1.0.",
                    "type": "number"
                  },
                  "decompensated_liver": {
                    "description": "Decompensated liver (ascites, encephalopathy, coagulopathy, or coma) as assigned by the caller (Brahmer 2018). true or false. When true, grade is max(lab_grade, 4). magent does not examine the patient.",
                    "type": "boolean"
                  },
                  "symptomatic_liver_dysfunction": {
                    "description": "Symptomatic compensated hepatitis / liver dysfunction as assigned by the caller (Brahmer 2018). true or false. When true and decompensated_liver is false, grade is max(lab_grade, 3). magent does not examine the patient.",
                    "type": "boolean"
                  }
                },
                "required": [
                  "ast_u_l",
                  "ast_uln_u_l",
                  "alt_u_l",
                  "alt_uln_u_l",
                  "bilirubin_mg_dl",
                  "bilirubin_uln_mg_dl",
                  "decompensated_liver",
                  "symptomatic_liver_dysfunction"
                ],
                "type": "object"
              },
              "maxItems": 25,
              "minItems": 1,
              "type": "array"
            }
          },
          "required": [
            "items"
          ],
          "type": "object"
        },
        "headers": {
          "additionalProperties": {
            "type": "string"
          },
          "type": "object"
        },
        "method": {
          "const": "POST",
          "type": "string"
        },
        "type": {
          "const": "http",
          "type": "string"
        }
      },
      "required": [
        "type",
        "method"
      ],
      "type": "object"
    },
    "output": {
      "properties": {
        "example": {
          "type": "object"
        },
        "type": {
          "type": "string"
        }
      },
      "required": [
        "type"
      ],
      "type": "object"
    }
  },
  "required": [
    "input"
  ],
  "type": "object"
}

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