IMWG 2014 myeloma requiring therapy (Rajkumar 2014)

IMWG 2014 myeloma requiring therapy (Rajkumar 2014). Met when clonal BMPC ≥10% or biopsy-proven plasmacytoma plus ≥1 MDE: hypercalcemia, renal insufficiency, anemia, osteolytic lesion (CRAB), or BMPC ≥60%, involved:uninvolved FLC ratio ≥100 with involved FLC ≥100 mg/L, or >1 focal MRI lesion ≥5 mm (SLiM). Not a diagnosis. Not smouldering MM, MGUS, POEMS, or amyloid. Not Greipp ISS or R-ISS. magent does not assay calcium, creatinine, hemoglobin, or FLC, and does not read MRI.

Paid test badge: not yet. The checks above are free: we call the tool without paying and read the payment request it sends back. The Verified badge needs paid calls whose answers match the promised output, and nobody can buy a badge.

Endpoint

POST https://api.magentlab.com/api/calc/imwg_myeloma

Our checks, last 30 days

Example input (from the provider)

{
  "body": {
    "items": [
      {
        "anemia": false,
        "bmpc_ge_60": false,
        "clonal_bmpc_ge_10_or_plasmacytoma": true,
        "flc_ratio_ge_100": false,
        "hypercalcemia": true,
        "mri_gt_1_focal": false,
        "osteolytic_lesion": false,
        "renal_insufficiency": false
      },
      {
        "anemia": false,
        "bmpc_ge_60": false,
        "clonal_bmpc_ge_10_or_plasmacytoma": true,
        "flc_ratio_ge_100": false,
        "hypercalcemia": true,
        "mri_gt_1_focal": false,
        "osteolytic_lesion": false,
        "renal_insufficiency": false
      }
    ]
  },
  "method": "POST",
  "type": "http"
}

Promised output schema (from the provider)

{
  "$schema": "https://json-schema.org/draft/2020-12/schema",
  "properties": {
    "input": {
      "additionalProperties": false,
      "properties": {
        "body": {
          "additionalProperties": false,
          "properties": {
            "items": {
              "items": {
                "properties": {
                  "anemia": {
                    "description": "Anemia as assigned by the caller (Rajkumar 2014 CRAB): hemoglobin value >20 g/L below the lower limit of normal or hemoglobin <100 g/L. true or false. magent does not assay hemoglobin.",
                    "type": "boolean"
                  },
                  "bmpc_ge_60": {
                    "description": "Clonal bone marrow plasma cells \u226560%, as assigned by the caller (Rajkumar 2014 SLiM). true or false. magent does not read a marrow.",
                    "type": "boolean"
                  },
                  "clonal_bmpc_ge_10_or_plasmacytoma": {
                    "description": "Clonal bone marrow plasma cells \u226510% or biopsy-proven bony or extramedullary plasmacytoma, as assigned by the caller (Rajkumar 2014 IMWG entry for myeloma requiring therapy). true or false. When false, myeloma is false even if a myeloma-defining event is true. magent does not read a marrow or biopsy.",
                    "type": "boolean"
                  },
                  "flc_ratio_ge_100": {
                    "description": "Involved:uninvolved serum free light-chain ratio \u2265100 and involved free light chain \u2265100 mg/L, as assigned by the caller as this one flag (Rajkumar 2014 SLiM). true or false. magent does not assay free light chains.",
                    "type": "boolean"
                  },
                  "hypercalcemia": {
                    "description": "Hypercalcemia as assigned by the caller (Rajkumar 2014 CRAB): serum calcium >0.25 mmol/L (>1 mg/dL) above the upper limit of normal or >2.75 mmol/L (>11 mg/dL). true or false. magent does not assay calcium.",
                    "type": "boolean"
                  },
                  "mri_gt_1_focal": {
                    "description": ">1 focal lesion on MRI, each \u22655 mm, as assigned by the caller (Rajkumar 2014 SLiM). true or false. magent does not read MRI.",
                    "type": "boolean"
                  },
                  "osteolytic_lesion": {
                    "description": "One or more osteolytic lesions on skeletal radiography, CT, or PET-CT, as assigned by the caller (Rajkumar 2014 CRAB). If marrow clonal plasma cells are <10%, more than one bone lesion is required to distinguish solitary plasmacytoma; that is the caller\u2019s assignment of this flag. true or false. magent does not read imaging.",
                    "type": "boolean"
                  },
                  "renal_insufficiency": {
                    "description": "Renal insufficiency as assigned by the caller (Rajkumar 2014 CRAB): creatinine clearance <40 mL/min or serum creatinine >177 \u00b5mol/L (>2 mg/dL). true or false. magent does not assay creatinine.",
                    "type": "boolean"
                  }
                },
                "required": [
                  "clonal_bmpc_ge_10_or_plasmacytoma",
                  "hypercalcemia",
                  "renal_insufficiency",
                  "anemia",
                  "osteolytic_lesion",
                  "bmpc_ge_60",
                  "flc_ratio_ge_100",
                  "mri_gt_1_focal"
                ],
                "type": "object"
              },
              "maxItems": 25,
              "minItems": 1,
              "type": "array"
            }
          },
          "required": [
            "items"
          ],
          "type": "object"
        },
        "headers": {
          "additionalProperties": {
            "type": "string"
          },
          "type": "object"
        },
        "method": {
          "const": "POST",
          "type": "string"
        },
        "type": {
          "const": "http",
          "type": "string"
        }
      },
      "required": [
        "type",
        "method"
      ],
      "type": "object"
    },
    "output": {
      "properties": {
        "example": {
          "type": "object"
        },
        "type": {
          "type": "string"
        }
      },
      "required": [
        "type"
      ],
      "type": "object"
    }
  },
  "required": [
    "input"
  ],
  "type": "object"
}

This page as JSON