Lyon 2020 HFA-ICOS baseline CV risk before combination RAF and MEK inhibitors
Lyon 2020 HFA-ICOS baseline CV risk before combination RAF and MEK inhibitors. Very high if heart failure or cardiomyopathy; High if MI/CABG, stable angina, severe valvular disease, prior anthracycline, or ≥5 medium points; Medium if 2-4 medium points; Low if 0-1. Age ≥65 is Medium 1 only. LVEF 50-54 is Medium 2; this table has no printed LVEF <50 High row. Expert-opinion cardiotoxicity guide <2% / 2-9% / 10-19% / ≥20%. Not a treatment order.
Asked 1.4x its listed price for its own exampleour last check, 2026-09-28
1 of 1checks answered this week
315 msmedian answer time
$0.005listed price per call
$0.007price it asked us
Paid test badge: not yet. The checks above are free: we call the tool without paying and read the payment request it sends back. The Verified badge needs paid calls whose answers match the promised output, and nobody can buy a badge.
Endpoint
POST https://api.magentlab.com/api/calc/hfa_icos_raf_mek
| Category | Everything else |
|---|---|
| Provider host | api.magentlab.com |
| Networks | eip155:8453 |
| Payment schemes | exact |
| Self-reported calls, 30 days | 0 from 0 payers (the provider's figure, not ours) |
Our checks, last 30 days
| Day | Result | HTTP | Asked | Time |
|---|---|---|---|---|
| 2026-09-28 | valid payment request | 402 | $0.007 | 315 ms |
Example input (from the provider)
{
"body": {
"items": [
{
"age_years": 50,
"arrhythmia": false,
"ckd": false,
"current_or_significant_smoker": false,
"diabetes": false,
"elevated_bnp": false,
"elevated_troponin": false,
"heart_failure_or_cardiomyopathy": false,
"hypertension": false,
"lvef_percent": 60,
"mi_or_cabg": false,
"obesity": false,
"prior_anthracycline": false,
"prior_left_chest_or_mediastinal_rt": false,
"severe_valvular_heart_disease": false,
"stable_angina": false
},
{
"age_years": 50,
"arrhythmia": false,
"ckd": false,
"current_or_significant_smoker": false,
"diabetes": false,
"elevated_bnp": false,
"elevated_troponin": false,
"heart_failure_or_cardiomyopathy": false,
"hypertension": false,
"lvef_percent": 60,
"mi_or_cabg": false,
"obesity": false,
"prior_anthracycline": false,
"prior_left_chest_or_mediastinal_rt": false,
"severe_valvular_heart_disease": false,
"stable_angina": false
}
]
},
"method": "POST",
"type": "http"
}
Promised output schema (from the provider)
{
"$schema": "https://json-schema.org/draft/2020-12/schema",
"properties": {
"input": {
"additionalProperties": false,
"properties": {
"body": {
"additionalProperties": false,
"properties": {
"items": {
"items": {
"properties": {
"age_years": {
"description": "Age in whole years (18-100). Lyon 2020 RAF-MEK table: age \u226565 is Medium 1. There is no High age band on this table. magent does not read an identity document.",
"type": "integer"
},
"arrhythmia": {
"description": "Atrial fibrillation, atrial flutter, ventricular tachycardia, or ventricular fibrillation as assigned by the caller (Lyon 2020 RAF-MEK table footnote). true is Medium 1. magent does not read an ECG.",
"type": "boolean"
},
"ckd": {
"description": "Chronic kidney disease (estimated glomerular filtration rate <60 mL/min/1.73 m2) as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 1. magent does not compute eGFR.",
"type": "boolean"
},
"current_or_significant_smoker": {
"description": "Current smoker or significant smoking history as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 1.",
"type": "boolean"
},
"diabetes": {
"description": "Diabetes mellitus (glycated haemoglobin >7.0% or >53 mmol/mol, or on treatment) as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 1. magent does not assay haemoglobin A1c.",
"type": "boolean"
},
"elevated_bnp": {
"description": "Elevated baseline BNP or NT-proBNP above the local laboratory upper limit of normal as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 2. magent does not assay natriuretic peptides.",
"type": "boolean"
},
"elevated_troponin": {
"description": "Elevated baseline troponin above the local laboratory upper limit of normal as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 2. magent does not assay troponin.",
"type": "boolean"
},
"heart_failure_or_cardiomyopathy": {
"description": "Heart failure or cardiomyopathy as assigned by the caller (Lyon 2020 RAF-MEK table). true is Very high. magent does not diagnose heart failure.",
"type": "boolean"
},
"hypertension": {
"description": "Hypertension (systolic >140 mm Hg or diastolic >90 mm Hg, or on treatment) as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 2. magent does not measure blood pressure.",
"type": "boolean"
},
"lvef_percent": {
"description": "Baseline LVEF in whole percent (10-80) as assigned by the caller. 50-54 is Medium 2. \u226555 adds no points. This table has no printed LVEF <50 High row; LVEF <50 does not raise risk_level by itself. magent does not read an echocardiogram.",
"type": "integer"
},
"mi_or_cabg": {
"description": "Myocardial infarction or CABG as assigned by the caller (Lyon 2020 RAF-MEK table). true is High.",
"type": "boolean"
},
"obesity": {
"description": "Obesity (BMI >30 kg/m2) as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 1. magent does not compute BMI.",
"type": "boolean"
},
"prior_anthracycline": {
"description": "Prior anthracycline exposure as assigned by the caller (Lyon 2020 RAF-MEK table). true is High. magent does not read a chemotherapy record.",
"type": "boolean"
},
"prior_left_chest_or_mediastinal_rt": {
"description": "Prior radiotherapy to the left chest or mediastinum as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 2.",
"type": "boolean"
},
"severe_valvular_heart_disease": {
"description": "Severe valvular heart disease as assigned by the caller (Lyon 2020 RAF-MEK table). true is High.",
"type": "boolean"
},
"stable_angina": {
"description": "Stable angina as assigned by the caller (Lyon 2020 RAF-MEK table). true is High. magent does not diagnose angina.",
"type": "boolean"
}
},
"required": [
"age_years",
"lvef_percent",
"heart_failure_or_cardiomyopathy",
"mi_or_cabg",
"stable_angina",
"severe_valvular_heart_disease",
"prior_anthracycline",
"elevated_troponin",
"elevated_bnp",
"hypertension",
"prior_left_chest_or_mediastinal_rt",
"arrhythmia",
"diabetes",
"ckd",
"current_or_significant_smoker",
"obesity"
],
"type": "object"
},
"maxItems": 25,
"minItems": 1,
"type": "array"
}
},
"required": [
"items"
],
"type": "object"
},
"headers": {
"additionalProperties": {