Lyon 2020 HFA-ICOS baseline cardiovascular risk before HER2-targeted therapy (tr
Lyon 2020 HFA-ICOS baseline cardiovascular risk before HER2-targeted therapy (trastuzumab and related agents). Very high, high, medium, or low from published factors plus Medium 1/2 points; expert-opinion cardiotoxicity guide <2% / 2-9% / 10-19% / >=20%. Concurrent anthracycline is High; sequential anthracycline before HER2 is Medium 1. Deterministic published classification with citation; not a treatment order. magent does not measure LVEF or biomarkers.
Asked 1.4x its listed price for its own exampleour last check, 2026-09-28
1 of 1checks answered this week
334 msmedian answer time
$0.005listed price per call
$0.007price it asked us
Paid test badge: not yet. The checks above are free: we call the tool without paying and read the payment request it sends back. The Verified badge needs paid calls whose answers match the promised output, and nobody can buy a badge.
Endpoint
POST https://api.magentlab.com/api/calc/hfa_icos_her2
| Category | Everything else |
|---|---|
| Provider host | api.magentlab.com |
| Networks | eip155:8453 |
| Payment schemes | exact |
| Self-reported calls, 30 days | 0 from 0 payers (the provider's figure, not ours) |
Our checks, last 30 days
| Day | Result | HTTP | Asked | Time |
|---|---|---|---|---|
| 2026-09-28 | valid payment request | 402 | $0.007 | 334 ms |
Example input (from the provider)
{
"body": {
"items": [
{
"age_years": 50,
"anthracycline_before_her2": false,
"arrhythmia": false,
"ckd": false,
"concurrent_anthracycline_and_her2": false,
"current_or_significant_smoker": false,
"diabetes": false,
"elevated_bnp": false,
"elevated_troponin": false,
"heart_failure_or_cardiomyopathy": false,
"hypertension": false,
"lvef_percent": 60,
"mi_or_cabg": false,
"obesity": false,
"prior_left_chest_or_mediastinal_rt": false,
"prior_remote_anthracycline": false,
"prior_trastuzumab_cardiotoxicity": false,
"severe_valvular_heart_disease": false,
"stable_angina": false
},
{
"age_years": 50,
"anthracycline_before_her2": false,
"arrhythmia": false,
"ckd": false,
"concurrent_anthracycline_and_her2": false,
"current_or_significant_smoker": false,
"diabetes": false,
"elevated_bnp": false,
"elevated_troponin": false,
"heart_failure_or_cardiomyopathy": false,
"hypertension": false,
"lvef_percent": 60,
"mi_or_cabg": false,
"obesity": false,
"prior_left_chest_or_mediastinal_rt": false,
"prior_remote_anthracycline": false,
"prior_trastuzumab_cardiotoxicity": false,
"severe_valvular_heart_disease": false,
"stable_angina": false
}
]
},
"method": "POST",
"type": "http"
}
Promised output schema (from the provider)
{
"$schema": "https://json-schema.org/draft/2020-12/schema",
"properties": {
"input": {
"additionalProperties": false,
"properties": {
"body": {
"additionalProperties": false,
"properties": {
"items": {
"items": {
"properties": {
"age_years": {
"description": "Age in years (integer 18-100). Lyon 2020 exclusive bands: \u226580 is High; 65-79 is Medium 2 (2 points); younger than 65 does not score. Age 80 is High, not Medium 2.",
"type": "integer"
},
"anthracycline_before_her2": {
"description": "Current regimen includes anthracycline before HER2-targeted therapy, sequential not concurrent (Lyon 2020 HER2 table Medium 1). true or false. Ignored for points when concurrent_anthracycline_and_her2 is true.",
"type": "boolean"
},
"arrhythmia": {
"description": "Atrial fibrillation, atrial flutter, VT, or VF as assigned by the caller (Lyon 2020 HER2 table Medium 2). true or false. magent does not interpret the ECG.",
"type": "boolean"
},
"ckd": {
"description": "Chronic kidney disease as assigned by the caller (Lyon 2020 HER2 table Medium 1). true or false.",
"type": "boolean"
},
"concurrent_anthracycline_and_her2": {
"description": "Anthracycline and trastuzumab delivered concurrently on the current protocol (Lyon 2020 HER2 table footnote f; High). true or false. When true, anthracycline_before_her2 does not add Medium 1 points.",
"type": "boolean"
},
"current_or_significant_smoker": {
"description": "Current or significant smoking history as assigned by the caller (Lyon 2020 HER2 table Medium 1). true or false.",
"type": "boolean"
},
"diabetes": {
"description": "Diabetes mellitus as assigned by the caller (Lyon 2020 HER2 table Medium 1). true or false.",
"type": "boolean"
},
"elevated_bnp": {
"description": "Elevated BNP or NT-proBNP as assigned by the caller (Lyon 2020 HER2 table Medium 2). true or false. magent does not assay natriuretic peptides.",
"type": "boolean"
},
"elevated_troponin": {
"description": "Elevated troponin as assigned by the caller (Lyon 2020 HER2 table Medium 2). true or false. magent does not assay troponin.",
"type": "boolean"
},
"heart_failure_or_cardiomyopathy": {
"description": "Heart failure or cardiomyopathy as assigned by the caller (Lyon 2020 HER2 table Very high). true or false.",
"type": "boolean"
},
"hypertension": {
"description": "Hypertension as assigned by the caller (Lyon 2020 HER2 table Medium 1). true or false.",
"type": "boolean"
},
"lvef_percent": {
"description": "Left-ventricular ejection fraction percent (integer 10-80) as assigned by the caller. <50 is High; 50-54 is Medium 2 (2 points); \u226555 does not score. magent does not measure LVEF.",
"type": "integer"
},
"mi_or_cabg": {
"description": "Prior myocardial infarction or CABG as assigned by the caller (Lyon 2020 HER2 table High). true or false.",
"type": "boolean"
},
"obesity": {
"description": "Obesity as assigned by the caller (Lyon 2020 HER2 table Medium 1). true or false. magent does not compute BMI.",
"type": "boolean"
},
"prior_left_chest_or_mediastinal_rt": {
"description": "Prior left-chest or mediastinal radiotherapy as assigned by the caller (Lyon 2020 HER2 table Medium 2). true or false.",
"type": "boolean"
},
"prior_remote_anthracycline": {
"description": "Prior remote anthracycline for a previous malignancy, not the current protocol (Lyon 2020 HER2 table footnote g; Medium 2). true or false.",
"type": "boolean"
},
"prior_trastuzumab_cardiotoxicity": {
"description": "Prior trastuzumab cardiotoxicity as assigned by the caller (Lyon 2020 HER2 table Very high). true or false. magent does not review prior exposure.",
"type": "boolean"
},
"severe_valvular_heart_disease": {
"description": "Severe valvular heart disease as assigned by the caller (Lyon 2020 HER2 table High). true or false.",
"type": "boolean"
},
"stable_angina": {
"description": "Stable angina as assigned by the caller (Lyon 2020 HER2 table High). true or false.",
"type": "boolean"
}
},
"required": [
"age_years",
"lvef_percent",
"heart_failure_or_cardiomyopathy",
"prior_trastuzumab_cardiotoxicity",
"mi_or_cabg",
"stable_angina",
"severe_valvular_heart_disease",
"concurrent_anthracycline_and_her2",
"arrhythmia",
"elevated_troponin",
"elevated_bnp",
"prior_remote_anthracycli