Lyon 2020 HFA-ICOS baseline cardiovascular risk before second- or third-generati

Lyon 2020 HFA-ICOS baseline cardiovascular risk before second- or third-generation multi-targeted kinase inhibitors for CML targeting BCR-ABL. Class is very_high, high, medium, or low from published very-high and high factors plus Medium 1/2 points (0–1 low, 2–4 medium, ≥5 high). Caller assigns the 10-year CVD >20% threshold; magent does not compute that score. Not a medical device or treatment order.

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Endpoint

POST https://api.magentlab.com/api/calc/hfa_icos_bcr_abl

Our checks, last 30 days

Example input (from the provider)

{
  "body": {
    "items": [
      {
        "abpi_le_0_9": false,
        "age_years": 50,
        "arrhythmia": false,
        "arterial_thrombosis_with_tki": false,
        "arterial_vascular_disease": false,
        "bcr_abl_tki_mediated_lvsd": false,
        "ckd": false,
        "current_or_significant_smoker": false,
        "cvd_10y_risk_gt_20": false,
        "diabetes": false,
        "family_history_thrombophilia": false,
        "heart_failure_or_lvsd": false,
        "hyperlipidemia": false,
        "hypertension": false,
        "lvef_percent": 60,
        "obesity": false,
        "pulmonary_arterial_hypertension": false,
        "qtc_ms": 400,
        "sex": "female",
        "venous_thromboembolism": false
      },
      {
        "abpi_le_0_9": false,
        "age_years": 50,
        "arrhythmia": false,
        "arterial_thrombosis_with_tki": false,
        "arterial_vascular_disease": false,
        "bcr_abl_tki_mediated_lvsd": false,
        "ckd": false,
        "current_or_significant_smoker": false,
        "cvd_10y_risk_gt_20": false,
        "diabetes": false,
        "family_history_thrombophilia": false,
        "heart_failure_or_lvsd": false,
        "hyperlipidemia": false,
        "hypertension": false,
        "lvef_percent": 60,
        "obesity": false,
        "pulmonary_arterial_hypertension": false,
        "qtc_ms": 400,
        "sex": "female",
        "venous_thromboembolism": false
      }
    ]
  },
  "method": "POST",
  "type": "http"
}

Promised output schema (from the provider)

{
  "$schema": "https://json-schema.org/draft/2020-12/schema",
  "properties": {
    "input": {
      "additionalProperties": false,
      "properties": {
        "body": {
          "additionalProperties": false,
          "properties": {
            "items": {
              "items": {
                "properties": {
                  "abpi_le_0_9": {
                    "description": "Caller-assigned abnormal ankle-brachial pressure index (paper: ABPI \u22640.9). High. magent does not measure ABPI.",
                    "type": "boolean"
                  },
                  "age_years": {
                    "description": "Age in years (integer 18-100). Lyon 2020 BCR-ABL table: \u226575 High; 65-74 Medium 2; 60-64 Medium 1 (paper row Age \u226560 years under the higher bands); <60 none. Bands do not stack. magent does not examine the patient.",
                    "type": "integer"
                  },
                  "arrhythmia": {
                    "description": "Caller-assigned arrhythmia (paper: atrial fibrillation, atrial flutter, ventricular tachycardia, or ventricular fibrillation). Medium 2. magent does not read a rhythm strip.",
                    "type": "boolean"
                  },
                  "arterial_thrombosis_with_tki": {
                    "description": "Caller-assigned arterial thrombosis associated with a BCR-ABL TKI. Very high. magent does not diagnose thrombosis.",
                    "type": "boolean"
                  },
                  "arterial_vascular_disease": {
                    "description": "Caller-assigned arterial vascular disease (IHD, PCI, CABG, stable angina, TIA, stroke, or PVD). Very high. magent does not diagnose vascular disease.",
                    "type": "boolean"
                  },
                  "bcr_abl_tki_mediated_lvsd": {
                    "description": "Caller-assigned BCR-ABL TKI-mediated LVSD. High. magent does not attribute LVSD to a TKI.",
                    "type": "boolean"
                  },
                  "ckd": {
                    "description": "Caller-assigned chronic kidney disease (paper: eGFR <60 mL/min/1.73 m\u00b2). Medium 1. magent does not compute eGFR.",
                    "type": "boolean"
                  },
                  "current_or_significant_smoker": {
                    "description": "Caller-assigned current smoker or significant smoking history. High on this BCR-ABL table (not Medium 1). magent does not take a smoking history.",
                    "type": "boolean"
                  },
                  "cvd_10y_risk_gt_20": {
                    "description": "Caller-assigned paper row Cardiovascular disease 10-year risk score >20%. High. magent does not compute SCORE2, PCE, or any other 10-year CVD equation.",
                    "type": "boolean"
                  },
                  "diabetes": {
                    "description": "Caller-assigned diabetes (paper: HbA1c >7.0% or >53 mmol/mol, or on treatment). Medium 1. magent does not diagnose diabetes.",
                    "type": "boolean"
                  },
                  "family_history_thrombophilia": {
                    "description": "Caller-assigned family history of thrombophilia. Medium 1. magent does not take a family history.",
                    "type": "boolean"
                  },
                  "heart_failure_or_lvsd": {
                    "description": "Caller-assigned heart failure or left-ventricular systolic dysfunction. High. magent does not diagnose heart failure.",
                    "type": "boolean"
                  },
                  "hyperlipidemia": {
                    "description": "Caller-assigned hyperlipidemia (paper: non-HDL cholesterol >3.8 mmol/L or >145 mg/dL). Medium 1. magent does not assay lipids.",
                    "type": "boolean"
                  },
                  "hypertension": {
                    "description": "Caller-assigned hypertension (paper: SBP >140 mmHg or DBP >90 mmHg, or on treatment). Medium 2. magent does not measure blood pressure.",
                    "type": "boolean"
                  },
                  "lvef_percent": {
                    "description": "Left-ventricular ejection fraction in percent (10-80). <50 is High. This table has no 50-54 Medium 2 LVEF row; \u226550 adds no LVEF points. magent does not read an echocardiogram.",
                    "type": "number"
                  },
                  "obesity": {
                    "description": "Caller-assigned obesity (paper: BMI >30 kg/m\u00b2). Medium 1. magent does not compute BMI.",
                    "type": "boolean"
                  },
                  "pulmonary_arterial_hypertension": {
                    "description": "Caller-assigned pulmonary arterial hypertension (paper: peak systolic PAP \u226535 mmHg when estimated on echocardiography). High. magent does not estimate pulmonary pressure.",
                    "type": "boolean"
                  },
                  "qtc_ms": {
                    "description": "QTc in milliseconds (300-700). \u2265480 is High. Borderline Medium 2 is men 450\u2264QTc<480 and women 460\u2264QTc<480. magent does not measure QTc.",
                    "type": "number"
                  },
                  "sex": {
                    "description": "Sex male or female. Selects the borderline QTc Medium 2 window (men 450\u2264QTc<480; women 460\u2264QTc<480). magent does not read an ECG.",
                    "type": "string"
                  },
                  "venous_thromboembolism": {
                    "description": "Caller-assigned venous thromboembolism (DVT or PE). Medium 2. magent does not diagnose VTE.",
                    "type": "boolean"
                  }
                },
                "required": [
                  "age_years",
                  "sex",
                  "lvef_percent",
                  "qtc_ms",
                  "arterial_vascular_disease",
       

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