Tefferi 2018 GIPSS for primary myelofibrosis
Tefferi 2018 GIPSS for primary myelofibrosis: karyotype (favorable 0, unfavorable 1, VHR 2; caller assigns the three-tier class), absence of type 1/like CALR 1, ASXL1 1, SRSF2 1, U2AF1Q157 1 (not S34); max 6. Low 0, intermediate_1 1, intermediate_2 2, high ≥3. Published median (5-year) survivals 26.4 y (94%), 8.0 y (73%), 4.2 y (40%), 2 y (14%). Not DIPSS or MIPSS70-plus. magent does not karyotype or sequence.
Asked 1.4x its listed price for its own exampleour last check, 2026-09-28
1 of 1checks answered this week
269 msmedian answer time
$0.005listed price per call
$0.007price it asked us
Paid test badge: not yet. The checks above are free: we call the tool without paying and read the payment request it sends back. The Verified badge needs paid calls whose answers match the promised output, and nobody can buy a badge.
Endpoint
POST https://api.magentlab.com/api/calc/gipss
| Category | Everything else |
|---|---|
| Provider host | api.magentlab.com |
| Networks | eip155:8453 |
| Payment schemes | exact |
| Self-reported calls, 30 days | 0 from 0 payers (the provider's figure, not ours) |
Our checks, last 30 days
| Day | Result | HTTP | Asked | Time |
|---|---|---|---|---|
| 2026-09-28 | valid payment request | 402 | $0.007 | 269 ms |
Example input (from the provider)
{
"body": {
"items": [
{
"asxl1_mutated": false,
"calr_type1_like": true,
"karyotype": "favorable",
"srsf2_mutated": false,
"u2af1_q157_mutated": false
},
{
"asxl1_mutated": false,
"calr_type1_like": true,
"karyotype": "favorable",
"srsf2_mutated": false,
"u2af1_q157_mutated": false
}
]
},
"method": "POST",
"type": "http"
}
Promised output schema (from the provider)
{
"$schema": "https://json-schema.org/draft/2020-12/schema",
"properties": {
"input": {
"additionalProperties": false,
"properties": {
"body": {
"additionalProperties": false,
"properties": {
"items": {
"items": {
"properties": {
"asxl1_mutated": {
"description": "ASXL1 mutation as assigned by the caller (Tefferi 2018). true scores 1. magent does not sequence.",
"type": "boolean"
},
"calr_type1_like": {
"description": "Presence of a type 1/like CALR mutation as assigned by the caller (Tefferi 2018). false (absence) scores 1. true scores 0. Type 2/like CALR, JAK2, MPL, and triple-negative are absence of type 1/like CALR. magent does not sequence.",
"type": "boolean"
},
"karyotype": {
"description": "Tefferi 2018 revised three-tier karyotype as assigned by the caller (mutually exclusive). favorable is a normal karyotype or sole 13q\u2212, +9, 20q\u2212, chromosome 1 translocation/duplication, or sex chromosome abnormality including \u2212Y and scores 0. unfavorable is all other abnormalities and scores 1. vhr is very high risk: single/multiple \u22127, i(17q), inv(3)/3q21, 12p\u2212/12p11.2, 11q\u2212/11q23, +21, or other autosomal trisomies not including +8/+9 and scores 2. magent does not karyotype.",
"enum": [
"favorable",
"unfavorable",
"vhr"
],
"type": "string"
},
"srsf2_mutated": {
"description": "SRSF2 mutation as assigned by the caller (Tefferi 2018). true scores 1. magent does not sequence.",
"type": "boolean"
},
"u2af1_q157_mutated": {
"description": "U2AF1 Q157 mutation (Q157P or Q157R) as assigned by the caller (Tefferi 2018). true scores 1. U2AF1 S34 does not score. magent does not sequence.",
"type": "boolean"
}
},
"required": [
"karyotype",
"calr_type1_like",
"asxl1_mutated",
"srsf2_mutated",
"u2af1_q157_mutated"
],
"type": "object"
},
"maxItems": 25,
"minItems": 1,
"type": "array"
}
},
"required": [
"items"
],
"type": "object"
},
"headers": {
"additionalProperties": {
"type": "string"
},
"type": "object"
},
"method": {
"const": "POST",
"type": "string"
},
"type": {
"const": "http",
"type": "string"
}
},
"required": [
"type",
"method"
],
"type": "object"
},
"output": {
"properties": {
"example": {
"type": "object"
},
"type": {
"type": "string"
}
},
"required": [
"type"
],
"type": "object"
}
},
"required": [
"input"
],
"type": "object"
}