Maurer 2025 FLIPI24

Maurer 2025 FLIPI24: 24-month event probability in newly diagnosed follicular lymphoma from age (nonlinear, inflection at 75), hemoglobin, WBC, LDH/ULN, and beta-2 microglobulin. Table S5 Cox algorithm assuming R-CHOP or B-R-like immunochemotherapy and 50% anti-CD20 maintenance. Low/intermediate/high at 0.10 and 0.15. Not Solal-Céligny FLIPI 2004. Not a diagnosis or treatment order. magent does not assay labs.

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Endpoint

POST https://api.magentlab.com/api/calc/flipi24

Our checks, last 30 days

Example input (from the provider)

{
  "body": {
    "items": [
      {
        "age": 61,
        "b2m_mg_l": 2,
        "hemoglobin_g_dl": 13,
        "ldh_uln_ratio": 1,
        "wbc_10e9_l": 7
      },
      {
        "age": 61,
        "b2m_mg_l": 2,
        "hemoglobin_g_dl": 13,
        "ldh_uln_ratio": 1,
        "wbc_10e9_l": 7
      }
    ]
  },
  "method": "POST",
  "type": "http"
}

Promised output schema (from the provider)

{
  "$schema": "https://json-schema.org/draft/2020-12/schema",
  "properties": {
    "input": {
      "additionalProperties": false,
      "properties": {
        "body": {
          "additionalProperties": false,
          "properties": {
            "items": {
              "items": {
                "properties": {
                  "age": {
                    "description": "Age in years (integer 18-120). Maurer 2025 Table S5: no additional age effect 18-60; HR 1.01 per year 60-75 (beta 0.01); HR 1.05 per year 75-90 (extra beta 0.038). Age is clamped to 90 for the linear predictor. magent does not assign age.",
                    "type": "integer"
                  },
                  "b2m_mg_l": {
                    "description": "Beta-2 microglobulin in mg/L (0.1-40). Table S5 linear 1-10 mg/L, HR 1.17 per unit (beta 0.159); values outside 1-10 are clamped. magent does not assay B2M.",
                    "type": "number"
                  },
                  "hemoglobin_g_dl": {
                    "description": "Hemoglobin in g/dL (1-25). Table S5 linear 8-17 g/dL, HR 0.92 per unit (beta -0.081); values outside 8-17 are clamped. magent does not assay hemoglobin.",
                    "type": "number"
                  },
                  "ldh_uln_ratio": {
                    "description": "Caller-assigned serum LDH divided by the local upper limit of normal (0.1-20). Table S5 linear 0.5-5, HR 1.44 per unit (beta 0.364); values outside 0.5-5 are clamped. magent does not measure LDH or set the ULN.",
                    "type": "number"
                  },
                  "wbc_10e9_l": {
                    "description": "White blood cell count in 10^9/L (0.1-80), equal to k/\u00b5L. Table S5 linear 4-11, HR 1.08 per unit (beta 0.075); values outside 4-11 are clamped. magent does not assay WBC.",
                    "type": "number"
                  }
                },
                "required": [
                  "age",
                  "hemoglobin_g_dl",
                  "wbc_10e9_l",
                  "ldh_uln_ratio",
                  "b2m_mg_l"
                ],
                "type": "object"
              },
              "maxItems": 25,
              "minItems": 1,
              "type": "array"
            }
          },
          "required": [
            "items"
          ],
          "type": "object"
        },
        "headers": {
          "additionalProperties": {
            "type": "string"
          },
          "type": "object"
        },
        "method": {
          "const": "POST",
          "type": "string"
        },
        "type": {
          "const": "http",
          "type": "string"
        }
      },
      "required": [
        "type",
        "method"
      ],
      "type": "object"
    },
    "output": {
      "properties": {
        "example": {
          "type": "object"
        },
        "type": {
          "type": "string"
        }
      },
      "required": [
        "type"
      ],
      "type": "object"
    }
  },
  "required": [
    "input"
  ],
  "type": "object"
}

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