Dutch Lipid Clinic Network (Nordestgaard 2013 Table 1) familial hypercholesterol

Dutch Lipid Clinic Network (Nordestgaard 2013 Table 1) familial hypercholesterolaemia score. One LDL (mmol/L or mg/dL / 38.67) plus family, clinical, physical, and DNA groups; per group only the highest. Max 26. Definite >8, probable 6-8, possible 3-5, unlikely 0-2. Score 8 (mutation alone) is probable. Adult Table 1 only; not Simon Broome, not MEDPED, not homozygous FH. magent does not assay lipids, examine tendons or arcus, or sequence genes. Not a medical device and not a diagnosis of FH.

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Endpoint

POST https://api.magentlab.com/api/calc/dutch_fh

Our checks, last 30 days

Example input (from the provider)

{
  "body": {
    "items": [
      {
        "causative_mutation_ldlr_apob_pcsk9": false,
        "child_ldl_gt_95th": false,
        "corneal_arcus_age_lt_45": false,
        "first_degree_ldl_gt_95th": false,
        "first_degree_premature_chd": false,
        "first_degree_xanthoma_or_arcus": false,
        "ldl_mg_dl": 348,
        "ldl_mmol_l": 9,
        "premature_cerebral_or_pvd": false,
        "premature_chd": false,
        "tendon_xanthoma": true
      },
      {
        "causative_mutation_ldlr_apob_pcsk9": false,
        "child_ldl_gt_95th": false,
        "corneal_arcus_age_lt_45": false,
        "first_degree_ldl_gt_95th": false,
        "first_degree_premature_chd": false,
        "first_degree_xanthoma_or_arcus": false,
        "ldl_mg_dl": 348,
        "ldl_mmol_l": 9,
        "premature_cerebral_or_pvd": false,
        "premature_chd": false,
        "tendon_xanthoma": true
      }
    ]
  },
  "method": "POST",
  "type": "http"
}

Promised output schema (from the provider)

{
  "$schema": "https://json-schema.org/draft/2020-12/schema",
  "properties": {
    "input": {
      "additionalProperties": false,
      "properties": {
        "body": {
          "additionalProperties": false,
          "properties": {
            "items": {
              "items": {
                "properties": {
                  "causative_mutation_ldlr_apob_pcsk9": {
                    "description": "Causative mutation in LDLR, APOB, or PCSK9 as assigned by the caller (Nordestgaard 2013 Table 1 DNA analysis, 8 points). true or false. magent does not sequence genes. Mutation alone is probable (score 8), not definite.",
                    "type": "boolean"
                  },
                  "child_ldl_gt_95th": {
                    "description": "Child under 18 years with LDL cholesterol above the 95th percentile (Nordestgaard 2013 Table 1 family history, 2 points). true or false as assigned by the caller. magent does not assay lipids or take a pedigree.",
                    "type": "boolean"
                  },
                  "corneal_arcus_age_lt_45": {
                    "description": "Arcus cornealis before age 45 years (Nordestgaard 2013 Table 1 physical examination, 4 points). true or false as assigned by the caller. magent does not examine the cornea or compute age.",
                    "type": "boolean"
                  },
                  "first_degree_ldl_gt_95th": {
                    "description": "First-degree relative with LDL cholesterol above the 95th percentile (Nordestgaard 2013 Table 1 family history, 1 point). true or false as assigned by the caller. magent does not assay lipids or take a pedigree.",
                    "type": "boolean"
                  },
                  "first_degree_premature_chd": {
                    "description": "First-degree relative with premature coronary heart disease (Nordestgaard 2013 Table 1 family history, 1 point). true or false as assigned by the caller. magent does not take a pedigree. Either this or first_degree_ldl_gt_95th scores 1 for the family group; a 2-point family item still yields family 2, not 3.",
                    "type": "boolean"
                  },
                  "first_degree_xanthoma_or_arcus": {
                    "description": "First-degree relative with tendon xanthoma and/or arcus cornealis (Nordestgaard 2013 Table 1 family history, 2 points). true or false as assigned by the caller. magent does not examine relatives. Either this or child_ldl_gt_95th scores 2 for the family group (max of family items).",
                    "type": "boolean"
                  },
                  "ldl_mg_dl": {
                    "description": "LDL cholesterol in mg/dL (40-800). Converted to mmol/L as mg/dL / 38.67, then scored on the mmol/L bands. Provide exactly one lipid parameter.",
                    "type": "number"
                  },
                  "ldl_mmol_l": {
                    "description": "LDL cholesterol in mmol/L (1-20). Nordestgaard 2013 Table 1 bands: >8.5 \u2192 8, 6.5-8.4 \u2192 5, 5.0-6.4 \u2192 3, 4.0-4.9 \u2192 1. Provide exactly one of ldl_mmol_l or ldl_mg_dl. magent does not assay lipids.",
                    "type": "number"
                  },
                  "premature_cerebral_or_pvd": {
                    "description": "Premature cerebral or peripheral vascular disease in the subject (Nordestgaard 2013 Table 1 clinical history, 1 point). true or false as assigned by the caller. magent does not diagnose vascular disease.",
                    "type": "boolean"
                  },
                  "premature_chd": {
                    "description": "Premature coronary heart disease in the subject (Nordestgaard 2013 Table 1 clinical history, 2 points; men <55 years / women <60 years as assigned by the caller). true or false. magent does not diagnose CHD or compute age or sex. If premature_cerebral_or_pvd is also true, the clinical group is 2, not 3.",
                    "type": "boolean"
                  },
                  "tendon_xanthoma": {
                    "description": "Tendon xanthoma in the subject (Nordestgaard 2013 Table 1 physical examination, 6 points). true or false as assigned by the caller. magent does not examine tendons. If corneal_arcus_age_lt_45 is also true, the physical group is 6, not 10.",
                    "type": "boolean"
                  }
                },
                "required": [
                  "first_degree_premature_chd",
                  "first_degree_ldl_gt_95th",
                  "first_degree_xanthoma_or_arcus",
                  "child_ldl_gt_95th",
                  "premature_chd",
                  "premature_cerebral_or_pvd",
                  "tendon_xanthoma",
                  "corneal_arcus_age_lt_45",
                  "causative_mutation_ldlr_apob_pcsk9"
                ],
                "type": "object"
              },
              "maxItems": 25,
              "minItems": 1,
              "type": "array"
            }
          },
          "required": [
            "items"
          ],
          "type": "object"
        },
        "headers": {
          "additionalProperties": {
            "type": "string"
          },
          "type": "object"
        },
        "method": {
          "const": "POST",
          "type": "string"
        },
        "type": {
          "const": "http",
          "type": "string"
        }
      },
      "required": [
        "type",
        "method"
      ],
      "type": "object"
    },
    "output": {
      "properties": {
        "example": {
          "type": "object"
        },
        "type": {
          "type": "string"
        }
      },
      "required": [
        "type"
      ],
      "type": "object"
    }
  },
  "required": [
    "input"
  ],
  "type": "object"
}

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