Titulaer 2011 DELTA-P for SCLC association in Lambert-Eaton myasthenic syndrome

Titulaer 2011 DELTA-P for SCLC association in Lambert-Eaton myasthenic syndrome. One point each, at or within 3 months of LEMS onset: bulbar weakness (dysarthria/dysphagia/chewing/neck weakness); erectile dysfunction if male (always 0 if female); weight loss ≥5%; smoking at onset; age ≥50; Karnofsky <70. Max 6. Bands low 0-1, intermediate 2, high 3-6. Published SCLC percents for scores 0, 1, 3-6; none for score 2. Not a LEMS diagnosis, not SOX1, and not an SCLC screen.

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Endpoint

POST https://api.magentlab.com/api/calc/delta_p

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Example input (from the provider)

{
  "body": {
    "items": [
      {
        "age": 40,
        "bulbar_weakness": false,
        "erectile_dysfunction": false,
        "kps_lt_70": false,
        "sex": "female",
        "smoking_at_onset": false,
        "weight_loss_ge_5pct": false
      },
      {
        "age": 40,
        "bulbar_weakness": false,
        "erectile_dysfunction": false,
        "kps_lt_70": false,
        "sex": "female",
        "smoking_at_onset": false,
        "weight_loss_ge_5pct": false
      }
    ]
  },
  "method": "POST",
  "type": "http"
}

Promised output schema (from the provider)

{
  "$schema": "https://json-schema.org/draft/2020-12/schema",
  "properties": {
    "input": {
      "additionalProperties": false,
      "properties": {
        "body": {
          "additionalProperties": false,
          "properties": {
            "items": {
              "items": {
                "properties": {
                  "age": {
                    "description": "Age at LEMS onset in years (18-120). \u226550 scores 1; 49 does not (Titulaer 2011).",
                    "type": "integer"
                  },
                  "bulbar_weakness": {
                    "description": "Dysarthria, dysphagia, chewing difficulty, or neck weakness at or within 3 months of LEMS onset (Titulaer 2011 D). true or false. Caller-assigned. 1 point if true.",
                    "type": "boolean"
                  },
                  "erectile_dysfunction": {
                    "description": "Erectile dysfunction at or within 3 months of LEMS onset (Titulaer 2011 E). Required when sex is male (true scores 1). When female, this item is always 0, including if omitted, false, or true. true or false.",
                    "type": "boolean"
                  },
                  "kps_lt_70": {
                    "description": "Karnofsky Performance Status 0-60 (KPS <70) at or within 3 months of LEMS onset (Titulaer 2011 P). Caller-assigned flag; magent does not compute Karnofsky. true or false. 1 point if true.",
                    "type": "boolean"
                  },
                  "sex": {
                    "description": "female or male. Erectile dysfunction scores only when male. Female erectile is always 0 (Titulaer 2011: Female | 0).",
                    "enum": [
                      "female",
                      "male"
                    ],
                    "type": "string"
                  },
                  "smoking_at_onset": {
                    "description": "Smoking at LEMS onset (Titulaer 2011 T). true or false. Caller-assigned. 1 point if true.",
                    "type": "boolean"
                  },
                  "weight_loss_ge_5pct": {
                    "description": "Weight loss \u22655% at or within 3 months of LEMS onset (Titulaer 2011 L). true or false. Caller-assigned. 1 point if true.",
                    "type": "boolean"
                  }
                },
                "required": [
                  "sex",
                  "age",
                  "bulbar_weakness",
                  "weight_loss_ge_5pct",
                  "smoking_at_onset",
                  "kps_lt_70"
                ],
                "type": "object"
              },
              "maxItems": 25,
              "minItems": 1,
              "type": "array"
            }
          },
          "required": [
            "items"
          ],
          "type": "object"
        },
        "headers": {
          "additionalProperties": {
            "type": "string"
          },
          "type": "object"
        },
        "method": {
          "const": "POST",
          "type": "string"
        },
        "type": {
          "const": "http",
          "type": "string"
        }
      },
      "required": [
        "type",
        "method"
      ],
      "type": "object"
    },
    "output": {
      "properties": {
        "example": {
          "type": "object"
        },
        "type": {
          "type": "string"
        }
      },
      "required": [
        "type"
      ],
      "type": "object"
    }
  },
  "required": [
    "input"
  ],
  "type": "object"
}

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