Garibaldi 2020 CIRC day-2/4/7 probability of severe disease or death from admiss

Garibaldi 2020 CIRC day-2/4/7 probability of severe disease or death from admission age, nursing-home residence, caller-assigned race term, Charlson CCI, BMI, symptoms, vitals, and listed laboratories. Appendix Table 1 coefficients on the printed reference cumulative incidences. Not a diagnosis, triage order, or the death-only Appendix Table 2 model.

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Endpoint

POST https://api.magentlab.com/api/calc/circ

Our checks, last 30 days

Example input (from the provider)

{
  "body": {
    "items": [
      {
        "age": 65,
        "albumin_g_dl": 3.7,
        "alt_u_l": 30,
        "bmi": 30,
        "cci": 0,
        "constitutional_symptoms": false,
        "crp_mg_dl": 5.7,
        "d_dimer_gt_1": false,
        "ferritin_ng_ml": 545,
        "fever": false,
        "gastrointestinal_symptoms": false,
        "gfr": 71,
        "hemoglobin_g_dl": 12.9,
        "leukocyte_k": 6.8,
        "loss_of_taste_smell": false,
        "lymphocyte_k": 1,
        "nursing_home": false,
        "pulse": 85,
        "race": "white",
        "respiratory_rate": 21,
        "respiratory_symptoms": false,
        "sex": "female",
        "troponin_detectable": false
      },
      {
        "age": 65,
        "albumin_g_dl": 3.7,
        "alt_u_l": 30,
        "bmi": 30,
        "cci": 0,
        "constitutional_symptoms": false,
        "crp_mg_dl": 5.7,
        "d_dimer_gt_1": false,
        "ferritin_ng_ml": 545,
        "fever": false,
        "gastrointestinal_symptoms": false,
        "gfr": 71,
        "hemoglobin_g_dl": 12.9,
        "leukocyte_k": 6.8,
        "loss_of_taste_smell": false,
        "lymphocyte_k": 1,
        "nursing_home": false,
        "pulse": 85,
        "race": "white",
        "respiratory_rate": 21,
        "respiratory_symptoms": false,
        "sex": "female",
        "troponin_detectable": false
      }
    ]
  },
  "method": "POST",
  "type": "http"
}

Promised output schema (from the provider)

{
  "$schema": "https://json-schema.org/draft/2020-12/schema",
  "properties": {
    "input": {
      "additionalProperties": false,
      "properties": {
        "body": {
          "additionalProperties": false,
          "properties": {
            "items": {
              "items": {
                "properties": {
                  "age": {
                    "description": "Age in years (integer 18-120). Appendix Table 1 bands: <60 (term -0.61), 60-74 (reference 0), >=75 (term -0.71). Derivation excluded ages under 18.",
                    "type": "integer"
                  },
                  "albumin_g_dl": {
                    "description": "Albumin in g/dL (1-6). Appendix Table 1: 0.23 per 0.5 g/dL decrease below 4 g/dL (no term when albumin >= 4). Reference 3.7.",
                    "type": "number"
                  },
                  "alt_u_l": {
                    "description": "Alanine aminotransferase in U/L (1-2000). Appendix Table 1: 0.02 times the natural log. Reference 30.0.",
                    "type": "number"
                  },
                  "bmi": {
                    "description": "Body mass index in kg/m2 (10-80). Appendix Table 1: 0.17 per increment of 5 kg/m2 versus the reference BMI of 30. obesity in the response is BMI >= 30.",
                    "type": "number"
                  },
                  "cci": {
                    "description": "Caller-assigned Charlson comorbidity index (integer 0-37). Appendix Table 1 per 1-point: 0.19 if age<60, -0.23 if age 60-74, 0.14 if age>=75. Reference CCI 0. magent does not assign Charlson diagnoses.",
                    "type": "integer"
                  },
                  "constitutional_symptoms": {
                    "description": "Constitutional symptoms present vs absent as assigned by the caller. false is the reference. true adds -0.57.",
                    "type": "boolean"
                  },
                  "crp_mg_dl": {
                    "description": "C-reactive protein in mg/dL (0.1-50). Appendix Table 1: 0.20 times the natural log. Reference 5.7.",
                    "type": "number"
                  },
                  "d_dimer_gt_1": {
                    "description": "D-dimer above the Appendix Table 1 threshold (>1 mg/dL FEU) as assigned by the caller. false is the reference. true adds 0.24.",
                    "type": "boolean"
                  },
                  "ferritin_ng_ml": {
                    "description": "Ferritin in ng/mL (10-20000). Appendix Table 1: 0.11 times the natural log. Reference 545.",
                    "type": "number"
                  },
                  "fever": {
                    "description": "Temperature >38.0 C within 24 hours of admission as assigned by the caller. false is the reference. true adds 0.56.",
                    "type": "boolean"
                  },
                  "gastrointestinal_symptoms": {
                    "description": "Gastrointestinal symptoms present vs absent as assigned by the caller. false is the reference. true adds -0.14.",
                    "type": "boolean"
                  },
                  "gfr": {
                    "description": "GFR in mL/min per 1.73 m2 (5-150). Appendix Table 1: -0.03 per increase of 10 versus the reference 71.",
                    "type": "number"
                  },
                  "hemoglobin_g_dl": {
                    "description": "Hemoglobin in g/dL (4-20). Appendix Table 1: 0.04 per 1-point decrease versus the reference 12.9 g/dL.",
                    "type": "number"
                  },
                  "leukocyte_k": {
                    "description": "Leukocyte count in K cells/mm3 (0.5-100). Appendix Table 1: -0.06 times the natural log. Reference 6.8.",
                    "type": "number"
                  },
                  "loss_of_taste_smell": {
                    "description": "Loss of taste and smell present vs absent as assigned by the caller. false is the reference. true adds -0.30.",
                    "type": "boolean"
                  },
                  "lymphocyte_k": {
                    "description": "Absolute lymphocyte count in K cells/mm3 (0.1-10). Appendix Table 1: -0.29 times the natural log. Reference 1.0.",
                    "type": "number"
                  },
                  "nursing_home": {
                    "description": "Admitted from a nursing home as assigned by the caller. false is the reference (0). true adds -0.24 if age<75, -0.22 if age>=75.",
                    "type": "boolean"
                  },
                  "pulse": {
                    "description": "Pulse in beats/min (30-220). Appendix Table 1: -0.02 per increment of 10 versus the reference pulse of 85.",
                    "type": "number"
                  },
                  "race": {
                    "description": "Caller-assigned Garibaldi 2020 paper term Non-White race vs White race. white is the reference (0). nonwhite adds 0.08. magent does not assign race.",
                    "enum": [
                      "white",
                      "nonwhite"
                    ],
                    "type": "string"
                  },
                  "respiratory_rate": {
                    "description": "Respiratory rate in breaths/min (6-60). Appendix Table 1 linear spline with knot at 18: -0.25 per unit below 18, 0.13 per unit at or above 18. Reference RR 21.",
                    "type": "number"
                  },
                  "respiratory_symptoms": {
                    "description": "Respiratory symptoms present vs absent as assigned by the caller. false is the reference. true adds 0.81.",
                    "type": "boolean"
                  },
                  "sex": {
                    "description": "Sex as assigned by the caller. female is the Appendix Table 1 reference (0). male adds 0.31 if age<60, -0.47 if age 60-74, 0.10 if age>=75. magent does not assign sex."

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