{"slug":"api-magentlab-com-api-calc-r-iss-e355b3","title":"Palumbo 2015 R-ISS for multiple myeloma","host":"api.magentlab.com","method":"POST","resource":"https://api.magentlab.com/api/calc/r_iss","category":"other","description":"Palumbo 2015 R-ISS for multiple myeloma. ISS from beta-2 microglobulin and albumin (Greipp 2005). R-ISS I: ISS I, standard-risk iFISH CA, and normal LDH. R-ISS III: ISS III plus high-risk CA (del(17p) and/or t(4;14) and/or t(14;16)) or LDH > ULN. R-ISS II: all other combinations. Not a myeloma diagn","price_listed":0.005,"price_asked":0.005,"state":"answering","state_label":"Answering","checks_7d":1,"answered_7d":1,"latency_ms_median":266,"reported_calls_30d":0,"reported_payers_30d":0,"networks":["eip155:8453"],"badge":"unverified","paid_checks_7d":0,"paid_ok_7d":0,"example_input":{"body":{"items":[{"albumin_g_dl":4,"albumin_g_l":40,"beta2_microglobulin_mg_l":2,"high_risk_ca":false,"ldh_gt_uln":false},{"albumin_g_dl":4,"albumin_g_l":40,"beta2_microglobulin_mg_l":2,"high_risk_ca":false,"ldh_gt_uln":false}]},"method":"POST","type":"http"},"output_schema":{"$schema":"https://json-schema.org/draft/2020-12/schema","properties":{"input":{"additionalProperties":false,"properties":{"body":{"additionalProperties":false,"properties":{"items":{"items":{"properties":{"albumin_g_dl":{"description":"Serum albumin in g/dL (1-6). Provide this or albumin_g_l, not both. ISS uses g/dL. Stage I requires albumin >= 3.5 when Sβ2M < 3.5. Ignored when Sβ2M >= 5.5.","type":"number"},"albumin_g_l":{"description":"Serum albumin in g/L (10-60). Converted as g/dL = g/L / 10. Provide this or albumin_g_dl, not both.","type":"number"},"beta2_microglobulin_mg_l":{"description":"Serum beta-2 microglobulin in mg/L (0.2-40). Greipp 2005 / Palumbo 2015 ISS. Stage I requires < 3.5; stage III when >= 5.5. magent does not assay beta-2 microglobulin.","type":"number"},"high_risk_ca":{"description":"High-risk cytogenetic abnormalities as assigned by the caller: true iff del(17p) and/or t(4;14) and/or t(14;16) by iFISH (Palumbo 2015). magent does not FISH.","type":"boolean"},"ldh_gt_uln":{"description":"Serum LDH greater than the upper limit of normal as assigned by the caller (Palumbo 2015: high LDH is > ULN). magent does not assay LDH or assign ULN.","type":"boolean"}},"required":["beta2_microglobulin_mg_l","high_risk_ca","ldh_gt_uln"],"type":"object"},"maxItems":25,"minItems":1,"type":"array"}},"required":["items"],"type":"object"},"headers":{"additionalProperties":{"type":"string"},"type":"object"},"method":{"const":"POST","type":"string"},"type":{"const":"http","type":"string"}},"required":["type","method"],"type":"object"},"output":{"properties":{"example":{"type":"object"},"type":{"type":"string"}},"required":["type"],"type":"object"}},"required":["input"],"type":"object"},"history":[{"day":"2026-09-28","reachable":true,"status":402,"valid_402":true,"asked_usdc":0.005,"price_match":true,"latency_ms":266,"error":null}],"description_full":"Palumbo 2015 R-ISS for multiple myeloma. ISS from beta-2 microglobulin and albumin (Greipp 2005). R-ISS I: ISS I, standard-risk iFISH CA, and normal LDH. R-ISS III: ISS III plus high-risk CA (del(17p) and/or t(4;14) and/or t(14;16)) or LDH > ULN. R-ISS II: all other combinations. Not a myeloma diagnosis or treatment choice; not R2-ISS; not Durie-Salmon. magent does not assay beta-2 microglobulin, albumin, LDH, or cytogenetics.","last_updated":"2026-09-28T15:12:47.557Z","schemes":["exact"]}