{"slug":"api-magentlab-com-api-calc-icc-sm-021335","title":"ICC 2022 systemic mastocytosis (Arber 2022)","host":"api.magentlab.com","method":"POST","resource":"https://api.magentlab.com/api/calc/icc_sm","category":"other","description":"ICC 2022 systemic mastocytosis (Arber 2022). Met when major infiltrates (≥15 tryptase- and/or CD117-positive MCs in aggregates in BM or extracutaneous organ) alone, or ≥3 minors. Minors: >25% spindle or atypical immature morphology, KIT D816V or other activating KIT mutation, CD25/CD2/CD30, tryptase","price_listed":0.005,"price_asked":0.007,"state":"overcharges","state_label":"Asked 1.4x its listed price for its own example","checks_7d":1,"answered_7d":1,"latency_ms_median":324,"reported_calls_30d":0,"reported_payers_30d":0,"networks":["eip155:8453"],"badge":"unverified","paid_checks_7d":0,"paid_ok_7d":0,"example_input":{"body":{"items":[{"associated_myeloid_neoplasm":false,"atypical_or_spindle":false,"cd2_cd25_or_cd30":false,"kit_activating":false,"major_infiltrates":true,"tryptase_gt_20":false},{"associated_myeloid_neoplasm":false,"atypical_or_spindle":false,"cd2_cd25_or_cd30":false,"kit_activating":false,"major_infiltrates":true,"tryptase_gt_20":false}]},"method":"POST","type":"http"},"output_schema":{"$schema":"https://json-schema.org/draft/2020-12/schema","properties":{"input":{"additionalProperties":false,"properties":{"body":{"additionalProperties":false,"properties":{"items":{"items":{"properties":{"associated_myeloid_neoplasm":{"description":"Associated myeloid neoplasm (ICC SM-AMN) as assigned by the caller. When true, tryptase_gt_20 does not count as a minor. true or false. magent does not diagnose a myeloid neoplasm.","type":"boolean"},"atypical_or_spindle":{"description":">25% spindle-shaped or atypical immature morphology in bone marrow or extracutaneous sections, as assigned by the caller (Arber 2022 ICC SM minor). true or false. magent does not read slides.","type":"boolean"},"cd2_cd25_or_cd30":{"description":"Mast cells express CD25, CD2, and/or CD30 in addition to mast-cell markers, as assigned by the caller (Arber 2022 ICC SM minor; ICC adds CD30). true or false. magent does not phenotype mast cells.","type":"boolean"},"kit_activating":{"description":"KIT D816V or other activating KIT mutation in bone marrow, blood, or an extracutaneous organ, as assigned by the caller (Arber 2022 ICC SM minor; not codon-816-only). true or false. magent does not sequence KIT.","type":"boolean"},"major_infiltrates":{"description":"Multifocal dense infiltrates of tryptase- and/or CD117-positive mast cells (≥15 MCs in aggregates) in bone marrow or another extracutaneous organ, as assigned by the caller (Arber 2022 ICC SM major). true or false. magent does not read a biopsy.","type":"boolean"},"tryptase_gt_20":{"description":"Serum tryptase persistently >20 ng/mL as assigned by the caller (Arber 2022 ICC SM minor). Does not count when associated_myeloid_neoplasm is true (SM-AMN). true or false. magent does not assay tryptase.","type":"boolean"}},"required":["major_infiltrates","atypical_or_spindle","kit_activating","cd2_cd25_or_cd30","tryptase_gt_20","associated_myeloid_neoplasm"],"type":"object"},"maxItems":25,"minItems":1,"type":"array"}},"required":["items"],"type":"object"},"headers":{"additionalProperties":{"type":"string"},"type":"object"},"method":{"const":"POST","type":"string"},"type":{"const":"http","type":"string"}},"required":["type","method"],"type":"object"},"output":{"properties":{"example":{"type":"object"},"type":{"type":"string"}},"required":["type"],"type":"object"}},"required":["input"],"type":"object"},"history":[{"day":"2026-09-28","reachable":true,"status":402,"valid_402":true,"asked_usdc":0.007,"price_match":false,"latency_ms":324,"error":null}],"description_full":"ICC 2022 systemic mastocytosis (Arber 2022). Met when major infiltrates (≥15 tryptase- and/or CD117-positive MCs in aggregates in BM or extracutaneous organ) alone, or ≥3 minors. Minors: >25% spindle or atypical immature morphology, KIT D816V or other activating KIT mutation, CD25/CD2/CD30, tryptase >20 ng/mL (not counted in SM-AMN). Not a diagnosis. Not Valent 2016 WHO SM. Not WHO 5th/Khoury. Not cutaneous mastocytosis only. magent does not read a biopsy or assay tryptase.","last_updated":"2026-09-28T15:11:05.311Z","schemes":["exact"]}